Postdoctor in Neurochemistry of Alzheimer pathology
Göteborgs universitet / Kemistjobb / Göteborg
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hela Sverige The University of Gothenburg tackles society's challenges with diverse knowledge. 56 000 students and 6 600 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.
At the Institute of Neuroscience and Physiology, at the Sahlgrenska Academy, we conduct research and education covering a wide range of knowledge areas. The institute comprises five different departments: Clinical Neuroscience, Health and Rehabilitation, Pharmacology, Physiology and Psychiatry and Neurochemistry. The Institute of Neuroscience and Physiology, invites applications for a postdoctoral position at the Department of Psychiatry and Neurochemistry.
We are looking for a motivated and ambitious Postdoc fellow with extensive neurochemistry/neurobiology experience for studying Alzheimer pathology. The aim is to develop new biomarkers that reflect the mechanisms underlying Alzheimer pathology in the brain.
Subject area
Postdoctor in Neurochemistry of Alzheimer pathology
Subject area description
A pathological hallmark of Alzheimer's disease (AD) is the aggregation of beta-amyloid peptide into extracellular plaques and tau into intracellular tangles in the brain. New antibody therapies targeting those proteins give exciting but also ambiguous clinical results for treatment of AD which relates largely to the fact that it is still not fully resolved where and when AD pathology emerges in the brain. Hence there is a great need for a detailed understanding of early AD pathology and new biomarkers, that can be measured in cerebral spinal fluid (CSF) and blood, that reflect early pathology in the brain and facilitate an early and accurate diagnosis and prognosis of AD.
Job assignments
As part of this research, you will drive and be involved in several different both clinical- and preclinical projects for studying protein dynamics in AD (amyloid and Tau) pathology in brain tissue, CSF and blood. The aim is to understand the critical mechanisms in early AD pathology which in turn allows to develop new protein biomarkers that reflect this early brain pathology. The goal is to develop, establish and validate those markers in preclinical- and clinical neurochemical studies and eventually present and publish those findings in scientific articles. Analytical methods to be used include primarily immuno-methods and mass spectrometry such as immunohistochemistry (IHC), immunoprecipitation (IP), digital ELISA (SIMOA), laser microdissection (LMD) as well as mass spectrometric- (LCMS, IPMS) and biochemical- (Western blot, ELISA) characterization of protein biomarkers.
Eligibility
To qualify as a postdoctoral researcher the applicant should hold a PhD in a relevant subject e.g. biology, chemistry, biomedicine, pharmacy.
Since postdoctoral constitutes a qualifying appointment for junior researchers, we aim to target those who have a doctoral degree not older than 3 years from the application deadline.
Assessment
Candidates will be assessed based on documented scientific experience with focus on pathogenic mechanism of Alzheimer's disease, method development and analytical methods (e.g. mass spectrometrym Simoa) of biological samples. This should be documented by publications in international, peer-reviewed journals. Previous experience in mass spectrometry or alternatively neurochemical biomarker development for brain pathologies is a particular merit.
Ability to independently process data and write scientific publications is essential, as is the ability to be flexible and able to work independently. During assessment, account will be taken with respect to personal ability and qualifications. Very good proficiency in English is mandatory.
Employment
The employment is limited (temporary) for 24 months, 100% of full-time, and is placed at the Institute of Neuroscience and Physiology. Starting date; as soon as possible or as agreed.
For further information
If you have questions regarding the employment please contact Researcher Jörg Hanrieder, phone: +46 31 343 2377, e-mail:
jh@gu.se or Professor/Chief Physician Kaj Blennow, phone: +46 31 343 2377, e-mail:
kaj.blennow@neuro.gu.seManager in charge is Professor/Head of Department Henrik Zetterberg, phone: +46 768 672 647, e-mail:
henrik.zetterberg@clinchem.gu.seApplication documents are not to be submitted through the contact persons.
How to apply
In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system:
https://www.gu.se/en/about-the-university/work-at-the-university-of-gothenburg/vacancies It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.
Please enclose PhD certificate with the application.
Closing date: 2022-05-02
The University of Gothenburg promotes equal opportunities, equality and diversity.
Salary is determined on an individual basis.
Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.
The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.
Salaries are set individually at the University.
In accordance with the National Archives of Sweden's regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.
Varaktighet, arbetstid
Heltid/ Ej specificerat
Publiceringsdatum2022-04-11ErsättningFast lön
Så ansöker duSista dag att ansöka är 2022-05-02
Klicka på denna länk för att göra din ansökanFöretagGöteborgs Universitet
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Göteborgs Universitet (org.nr 202100-3153),
http://www.gu.se/ Arbetsplats Göteborgs universitet
Jobbnummer 6527205
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