PhD student position in medical science - Childhood acute myeloi
Göteborgs universitet / Administratörsjobb (offentlig verksamhet) / Göteborg
Observera att sista ansökningsdag har passerat.
Visa alla administratörsjobb (offentlig verksamhet) i Göteborg,
Mölndal,
Partille,
Kungälv,
Lerum eller i
hela Sverige Visa alla jobb hos Göteborgs universitet i Göteborg,
Partille,
Lysekil,
Uddevalla,
Vänersborg eller i
hela Sverige Kort beskrivning av företaget:
The University of Gothenburg tackles society's challenges with diverse knowledge. 37 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.
Titel:
PhD student position in medical science - Childhood acute myeloid leukemia with t(7;12)
Beskrivning av arbetsuppgifter: T
ype of employment: Fixed-term employment, 4 years Extent: 100 % Location: Sahlgrenska Academy, Gothenburg First day of employment: As agreed Reference number: UR 2016/18 Job assignments: Cytogenetic aberrations are often involved in the development of acute myeloid leukemia (AML) and they can serve as diagnostic markers, prognosis predictors and influence choice of therapy. Relatively recently a reciprocal, often cryptic, translocation t(7;12)(q36;p13) leading to a fusion between the genes MNX1 and ETV6, has been found in young children with AML. The mechanism for how this chromosomal aberration and its product may cause leukemia transformation is not understood. Also, the true incidence and thus the prognostic impact needs to be determined. The project includes the following: 1. Incidence and prognosis of AML with t(7;12)(q36;p13). Samples from all AML patients under the age of 24 months diagnosed in Sweden between 1993-2012 will be screened for t(7;12)(q36;p13) using FISH and RT-PCR. The prognostic impact will be assessed in the Nordic childhood AML treatment protocols using the NOPHO leukemia registry. 2. Mapping of additional genetic alterations in AML with t(7;12)(q36;p13). A comprehensive investigation with next generation sequencing of genetic and epigenetic changes will be done on selected samples collected at diagnosis and relapse. 3. Mechanisms for leukemia transformation induced by t(7;12)(q36;p13). The transformation capacity and the involved molecular mechanisms for leukemogenesis induced by MNX1-ETV6 will be assessed in vitro and in a murine bone marrow transplantation model in vivo. The thesis project spans over both experimental techniques and clinical studies and will lead to a deeper understanding of the mechanisms for leukemia development and improve diagnosis and treatment decisions in AML. The PhD position comprises 4 years full-time studies and leads to a doctoral degree. The position is funded via doctoral studentship.
Beskrivning av kvalifikationer:
Eligibility: To be admitted to third-cycle studies you must fulfill both the general and the specific entry requirements. The general entry requirements is fulfilled if you have: 1. completed a degree at a second-cycle level, or 2. completed at least 240 credits worth of studies of which at least 60 credits must be at a second-cycle level, or 3. acquired equivalent knowledge in some other way in Sweden or abroad. The specific entry requirements is fulfilled if you have completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.
Varaktighet, arbetstid
Visstidsanställning 6 månader eller längre
Heltid
Fixed-term employment, 4 years Tillträde
As agreed
Publiceringsdatum2016-01-29ErsättningFast månads- vecko- eller timlön
Så ansöker duSista dag att ansöka är 2016-02-22
Please apply online at the University of Gothenburg job application portal:
Klicka på denna länk för att göra din ansökanFöretagGöteborgs universitet
AdressGöteborgs universitet
Box 100
40530 GÖTEBORG
KontorsadressUniversitetsplatsen 1
Övriga kontaktuppgifterTelefonnummer: 031-7860000
Jobbnummer 2642609
Observera att sista ansökningsdag har passerat.