Target Validation Lead, Imed Ria Sweden
AstraZeneca / Biologjobb / Göteborg
2018-09-13
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➡️ Klicka här för den senare publicerade platsannonsen "Target Validation Lead, Imed Ria Sweden" (publicerad 2018-12-03) ⬅️
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hela Sverige Main Duties and Responsibilities
The RIA Target & Translational Sciences (TTS) department is an agile environment, with a culture that is science and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population, and close the gap between bench science and bedside clinical practice.
A key role of Precision Medicine Discovery is to lead the human validation of our targets, identify Proof-of Mechanism (PoM) biomarkers and deliver the line-of-sight for the target to clinic. Underpinned by a robust understanding of disease relevant pathways and drivers, the Target Validation Lead (TVL) is a key scientific role, building mechanistic understanding of the target and disease through innovative application of experimental methods and technologies. The TVL is a project and laboratory based scientist, with the critical accountabilities for identifying and enabling PoM biomarkers to demonstrate target engagement at First-Time-In-Man (FITM) and leading the pre-clinical target validation strategy from TSID. Working closely with the Translational Science Lead and Biomarker Discovery Scientists, other decision making and exploratory biomarkers will be identified and developed for each project. The TVL is accountable as member of the project iPT, from TSID to FTIM for decision making biomarkers, including PoM biomarkers, and the target validation strategy. The TVL will work with PMG labs to ensure decision making biomarkers are deployed in FTIM in line with GCP requirements.
Working with the Target Science Lead, the TVL will bridge the transition of a project as it enters the portfolio at TSID. Active collaborative working with the Target Validation Lead, Biomarker Discovery Scientists, Data Scientists, Experimental Medicine Scientists, Human Tissue Leads, other RIA departments, Discovery Science (DS) and Precision Medicine and Genomics (PMG) will be essential to continuously strengthen the link between targets and disease phenotypes and endotypes, and bring precision medicine propositions to the clinic. The TVL is both a project and laboratory role, requiring flexibility to ensure all translational aspects of the projects are supported in a timely fashion.
Accountabilities and responsibilities:
* Accountable for delivery of preclinical human validation of target (in relevant: in vivo models, cell types, tissue) by experimentally demonstrating presence and functional implication of the target in relevant disease mechanisms, mechanistic understanding of target and disease
* Responsible for the design, execution, interpretation and reporting of human Target Validation studies, ensuring timely delivery of experimental data to projects and reporting will be via relevant databases.
* Accountable to identify and develop PoM biomarkers, Decision Making and other Exploratory Biomarkers as required for each target.
* Develops target line of sight to clinic before FTIM.
* Responsible to align PoM and other biomarker strategies with the clinical development plan.
* Responsible to deliver thorugh Precision Medicine and Genomic Labs t robust assays to required regulatory standards.
* Builds IMED RIA mechanistic understanding of target and disease
* Works with Biomarker Discovery Scientists other parts of the organization such as DSM and DS to select relevant biomarker platforms, new technologies and methodologies to enable target validation e.g. CRISPR, Lung-on-a-chip technologies etc
* Works flexible from TSID to Ph1 as needed.
Essential Requirements
* PhD or equivalent with a strong experimental drive and background in basic science related to respiratory research.
* Post-doc experience or otherwise relevant scientific research experience.
* Experience in pharmaceutical R&D.
* Strong publication record.
* Demonstrable delivery in biomarkers and target validation and their application to drug discovery
* Excellent understanding of the Respiratory therapy area and disease biology, including molecular pathways and mechanisms related to respiratory diseases.
* Experience and knowledge of the biological basis for target engagement biomarkers and familiar with PoM biomarker invention and implementation.
* Broad understanding of relevant technologies and methodologies along with excellent scientific laboratory skills and ability to experimentally address key scientific questions.
* Broad understanding of several technologies and methodologies along with excellent scientific laboratory skills and ability to experimentally address key scientific questions.
* Excellent skills in hypothesis forming and testing, able to draw conclusions and suggest next steps based on the experimental data.
* Approx. 10 years of work experience in pharmaceutical R&D, from lead identification through clinical trials
*
If you are interested, apply now!
For more information about the position please contact Katerina Pardali,
Welcome with your application no later than September 30th, 2018.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2018-09-13ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2018-10-11
Ange följande referens när du ansöker: R-031621
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
karin.lyckemalm@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparredsleden 1
Jobbnummer 4346440
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