Post Doc Fellow - Advanced Drug Delivery (Sweden and USA placeme
AstraZeneca Göteborg / Apotekarjobb / Mölndal
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hela Sverige In January 2016, Pharmaceutical Sciences was established in the IMED organisation to ensure we implement intelligent design of medicines and delivery systems. The department is focussed on three priority areas - early chemical development, early product development and advanced drug delivery - while it supports synthesis, formulation and delivery for IMED's portfolio across the main therapy areas, from early discovery to Phase llB clinical trials.
Main duties and responsibilities
PostDoc long title: Designing non-immunogenic and effective lipid nanoparticle formulations for messenger-RNA (mRNA) delivery
Gene therapies such as mRNA have the potential to fill unmet medical needs and, hence, significantly improve human health. A major hurdle inhibiting the clinical testing of nucleic acid drugs such as RNAs is the design of efficacious delivery vehicles that do not induce immunogenicity. A frequently used delivery vehicle is the lipid nanoparticle (LNP), which, in addition to mediating effective mRNA delivery, can also cause toxicity and immunogenicity depending on the chemistry.
You'll be part of a project to test novel and safe, biodegradable lipids to replace traditional cationic lipids without sacrificing efficacy, as well as understand intracellular trafficking for the mRNA-loaded LNPs. More specifically, you'll characterise novel lipid library hits, develop LNP formulations, and test these models in biological systems for effects and side effects including detailed exploring of intracellular trafficking pathways. This part of the fellowship will be placed in AstraZeneca's facility in Gothenburg, Sweden. The knowledge gained will be used to design new and potentially even further improved lipids with our collaborator, Professor. Kathryn Whitehead, at Carnegie Mellon University in Pittsburgh, PA, USA. There will be opportunities to contribute to publications in the areas of lipid design, drug delivery and cell biology.
Essential requirements
PhD or equivalent qualification with specialisation in chemistry, drug delivery or molecular biology
Experience of writing scientific publications in peer reviewed journals
Verbal and written English fluency
Excellent communication and collaboration skills.
Desirable requirements
Knowledge of intra cellular trafficking mechanisms, endocytotic pathways, and assay design relevant to understanding cellular uptake and vesicle trafficking
Experience in lipid drug delivery system development and characterisation
Understanding of excipient design principles.
To apply for this position, please click the apply link below
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
This is a 2-year, fixed-term contract based in Gothenburg, Sweden, although a portion of the research will be undertaken at Carnegie Mellon University in Pittsburgh, PA, USA, with a competitive salary on offer.
At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you'll develop further and faster than you thought possible. We'll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expertise and build your skills. So if you're curious about what science can do, come and make a difference.
As a world leader in cardiovascular and metabolic medicines, we're always working on innovative new drugs that will change lives across the globe. To make that happen, we've divided our small molecule research strategy into three priorities: cardiac regeneration, islet health in diabetes and diabetic nephropathy. You'll focus your efforts on making real progress toward slowing, stopping or curing some of the most aggressive diseases that face humanity today.
Publiceringsdatum2017-02-27Så ansöker duSista dag att ansöka är 2017-04-17
Klicka på denna länk för att göra din ansökanFöretagAstraZeneca Göteborg
AdressAstraZeneca Göteborg
Pepparedsleden 1
43183 MÖLNDAL
KontorsadressPepparedsleden 1
Jobbnummer 3343289
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