Senior Scientist sökes omgående till AstraZeneca!
Adecco Sweden AB / Läkarjobb / Mölndal
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hela Sverige We are now looking for a Senior Scientist for a consultant assignment positioned at our customer AstraZeneca in Mölndal. Overall, the role involves method development for analysis of nucleotides and peptides, and is placed in a new global unit located under the Drug Safety Metabolism unit, supporting for instance cancer projects in the UK and the US. The assignment is to start immediately and proceed initially for 12 months.
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. AstraZeneca is more than one of the world's leading pharmaceutical companies. At AstraZeneca, they are proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity. AstraZeneca are building a new bioanalysis capability to support their nucleotide projects and they already have quite an active portfolio which requires immediate support hence the need for some contractors.
The arena
Innovative Medicines, Drug Safety and Metabolism, Translational Safety, Pre-clinical Bioanalysis & Toxickinetics (BA/TK).
The pre-clinical bioanalysis and TK group are responsible for the analysis of small molecule drug substances in biological samples generated in support of investigational toxicology studies and Pre FTIM Rodent GLP studies.
This new role will expand the remit of the team beyond small molecules by including nucleotide bioanalysis for toxicology and PK, PK/PD studies and encoded proteins for our modified mRNA projects.
The role
The successful candidate will be responsible for building a new DSM capability for analysis of nucleotide therapeutics and associated encoded proteins. This will involve defining necessary procedures, developing analytical methods using ligand binding techniques (e.g. ELISA, DNA hybridisation), implementation of the methods and supporting non-clinical studies. Experience of quantitative polymerase chain reaction and mass spectrometry based approaches would also be advantageous but is not essential.
The senior scientist is responsible for delivering quality in vivo PK data to support the nucleotide project portfolio. He/she develops methodology for quantification of oligonucleotide as well as encoded protein in plasma or other matrices using state of the art analytical techniques and reports methodology, data and PK evaluation to the customer.
The role requires the successful applicant to take a leading role in establishing the science and capability. The senior scientist would be involved in developing the strategy for the timing of activities and types of activities. The role requires interactive, effective communication providing clear data and interpretation to projects and contribution to the DMPK scientific strategy. The role requires making judgements about complex scientific information sets, developing innovative solutions and applying comprehensive cross-functional understanding.
In this role you are responsible for overseeing efficient and timely delivery of appropriate quality data
Qualifications and requirements
It is of advantage if you have an expertise in range to technical skills, specifically immunoassay/ELISA platforms (MSD, Gyros, Luminex etc), q-PCR, as well as mass spectrometry for analysis of large molecules and other automated processing and analysis equipment.
You ought to develop and set up bioanalytical methods for quantitative analysis of nucleotides (oligonucleotides, microRNA, modified mRNA) and encoded proteins for the modified mRNA projects.
You should be able to provide scientific leadership to scientists in BA/TK, coaching and mentoring for junior colleagues, motivational skills. Perform problem solving studies by identification of issues and where necessary designing experiments to overcome problems. Also influence study directors to ensure appropriate samples are taken to define the exposure and kinetics of the candidate drug.
Plan and report all work to appropriate standards (Good Laboratory Standard, GLS) and keep project teams apprised of findings. Significant experience in pharmacokinetics and reasonable understanding of PK/PD principle is of great importance. You should also be abloe to perform PK and TK calculations including interpretation of the data generated, in collaboration with colleagues in innovative medicines (e.g. DMPK and Toxicology project leaders). As a Senior Scientist you should as well be able to identify new approaches and technologies that would improve our ability to support projects. Assist in the identification and evaluation of contract research organisations and coordinate method transfer as required.
Maintain awareness of relevant areas of research, drug discover/development technologies and regulatory requirements through reading scientific literature and guidelines. It is important to be capable to represent function on appropriate teams (e.g. project or study teams) to ensure activities are conducted & also understand the strategy for drug development, particularly therapeutic nucleotides.
We are looking for someone with excellent communication skills, both verbal and written.
What do we offer?
Adecco is the world's largest recruitment and staffing company and our most important asset is our qualified employees. With us, and on our customer assignments, you, as a consultant, will be appreciated for your difference-making competence! Your bank of experience will grow, as will your social and professional network of contacts. Adecco can offer you the opportunity of interesting assignments at attractive companies, of positions that perhaps never will be put on the open market.
We want you to feel good and will give you subsidies for preventive healthcare and discounts on training cards. In order for you to feel secure, you will also be covered by insurance and corporate healthcare.
Are you interested?
Then you should apply as soon as possible! The positions are to be filled immediately, and, for that reason, work with recruitment is being done on a continual basis. Don't hesitate and apply now.
We strongly look forward to your application!
Publiceringsdatum2014-08-29Arbetstider och omfattningHeltid Visstid
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2014-09-28
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Klicka på denna länk för att göra din ansökanKontaktJoana Lotffi
FöretagAdecco Sweden AB
AdressAdecco Sweden AB
Götgatan 11
41105 GÖTEBORG
KontorsadressGötgatan 11
Övriga kontaktuppgifter Jobbnummer 1980371
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