Preclinical And Translational Pk & Pkpd Scientist
AstraZeneca AB / Biomedicinjobb / Göteborg
2019-11-25
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hela Sverige Visa alla jobb hos AstraZeneca AB i Göteborg,
Mölndal,
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Solna,
Stockholm eller i
hela Sverige Do you have expertise in pharmacokinetics and pharmacodynamics? Would you like to apply your expertise in a company that is accelerating innovative science and turns ideas into life changing medicines? Join us to be part of the development of future treatments of Cardiovascular, Renal and Metabolic diseases!
We are now recruiting a skilled and passionate scientist with expertise in pharmacokinetics-pharmacodynamics (PKPD) to join the Modelling & Simulation team within the DMPK department of the Early Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca. The position can be at Senior Scientist or Associate Principal Scientist level depending on the experience of the successful candidate and is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden.
Early CVRM is one of the three main therapeutic research areas within AstraZeneca which deliver candidate drugs into late-stage clinical development. Early CVRM is a global function with research units in Gaithersburg US, Cambridge UK and Gothenburg Sweden. The DMPK department is based in Sweden and work closely with other functions in supporting Early CVRM projects along the value chain, from target selection all the way to market launch and Life cycle management.
As a Senior PK and PKPD scientist within Early CVRM you will provide translational quantitative/pharmacokinetic-pharmacodynamic (PKPD) input globally for a broad range of drug modalities, from target identification to life-cycle management. You will thus be able to contribute with your solid PKPD understanding and hands-on mathematical modelling experience (e.g. empirical PKPD models, in vitro-in vivo translation, non-linear mixed effects models, mechanistic systems pharmacology models). In this role, you will get the opportunity to demonstrate and witness what science can do for the discovery of new life changing medicines for patients.
Main Duties and Responsibilities
* Define and deliver the translational quantitative/PKPD strategy in projects from target identification to life-cycle management ·Identify the appropriate mathematical modelling approach (e.g. traditional PKPD modelling, non-linear mixed effects modelling, quantitative systems pharmacology) to deliver the aforementioned
* Design preclinical PKPD studies, contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
* In collaboration with key functions (e.g. bioscientists, translational scientists, safety scientists, clinical pharmacologists and clinical pharmacometricians) integrate the appropriate data to predict human pharmacokinetics, efficacious human drug exposure, human longitudinal response (e.g. biomarker and disease effects), and human dosing regimen
* Communicate scientific progresses both externally and internally
Essential Requirements
* PhD in pharmacokinetics, pharmacology or related field, with focus on mathematical modelling of PKPD data, ideally in a preclinical/translational setting
* Specialist in PK and PKPD data analysis, interpretation, and reporting, including hands-on experience with modelling software (e.g. Phoenix, Matlab, Monolix, R, NONMEM, or similar)
* Excellent interpersonal skills, and ability to work in cross-functional teams as well as independently
* Experience in pharmaceutical R&D is an advantage
* Experience in defining quantitative modelling strategies across several therapeutic modalities (e.g. small molecules, oligonucleotides, peptides, proteins, antibodies) is an advantage
* Scientific leadership evidenced by a publication track record and ability to independently lead the drafting and review of manuscripts for publication
* Excellent communication skills in English, both verbal and in writing are required
We would like to know about you, if you are interested, apply now!
For more information, please contact recruiting manager Christine Ahlström at
Welcome with your application no later than December 15, 2018
Additional information
Our Gothenburg site:
https://www.astrazeneca.com/our-science/gothenburg.htmlLife in Gothenburg and Sweden:
https://www.movetogothenburg.com/Culture and atmosphere of the site:
https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/AstraZeneca is acting as an Employment Agency in relation to this vacancy.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2019-11-25ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2019-12-16
Klicka på denna länk för att göra din ansökanFöretagAstrazeneca AB
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-066455".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Jobbnummer 4973304
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