Postdoctoral fellow in Tumor immunology
Göteborgs universitet / Apotekarjobb / Göteborg
2013-07-12
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Postdoctoral fellow in Tumor immunology
Type of employment: Fixed-term employment, 2 years
Extent: 100 %
Location: Institute of Biomedicine, Sahlgrenska Cancer Center, Göteborg
First day of employment: As agreed
Reference number: PER 2013/328
The group focuses on the development of immunotherapies for myeloid leukemias in collaboration with several clinical hematology units. The group has initiated and conducted several phase II and phase III clinical trials in leukemia. For more information see:
http://www.cancercenter.gu.se/research/kristoffer-hellstrand/Subject area
Tumor immunology
Specific subject description
Reactive oxygen species (ROS or ?oxygen radicals?) produced by the NADPH oxidase of myeloid cells are potent inhibitors of cellular immunity by triggering programmed cell death and dysfunction in natural killer (NK) cells and T cells. Inhibition of NADPH oxidase-dependent ROS formation restores lymphocyte function and lymphocyte responsiveness to cytokines. An NADPH oxidase inhibitor (HDC) was recently approved in acute myeloid leukemia (AML) for the prevention of relapse among patients who have achieved complete remission after chemotherapy (Blood 108: 88-96). Recent studies from our group reveal that AML cells produce ROS and thus evade cell-mediated, anti-leukemic immunity (Blood 119: 5832-7).
Job assignments
The applicant will explore mechanisms of relevance to leukemia-induced immunosuppression using experimental in vivo and in vitro models and by analyzing clinical samples from patients undergoing HDC-based immunotherapy. The overriding goal is to provide a basis for the development of novel immunotherapies in AML and related diseases.
Eligibility
An achieved doctoral degree is compulsory for a position as postdoctor at the University of Gothenburg. The doctoral thesis shall be in the fields of medicine, biomedicine or biology. Since a position as postdoctor aims to give new holders of the doctorate the opportunity mainly to strengthen and develop their scholarly proficiency, we aim for those who have a doctoral degree not older than 3 years counting from last date of application (July 25th 2013).
Assessment
The applicant should have a background in immunology, microbiology with orientation towards immunology, hematology, or oncology. Experience of flow cytometry, advanced cell- and molecular biology and experimental animal models is desirable.
Publiceringsdatum2013-07-12Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2013-07-25
Appointment Procedure
Please apply online,
www.gu.se/jobs.The application should contain:
• A cover letter giving a brief description of previous research experience, and a motivation to why you are applying
• A CV including a list of publication,
• Contact details of two references
Ansökan kan tyvärr inte göras via e-post.
KontaktKristoffer Hellstrand, professor, M.D +46 31 788 6672
kristoffer.hellstrand@microbio.gu.seFacklig kontaktOFR/S Stefan Schedin, 031-786 11 67
stefan.schedin@socav.gu.seSACO: Catrine Forsnabba 031-786 2768
Catrine.Forsnabba@ped.gu.seSEKO: Lennart Olsson, 031-786 11 73
lennart.olsson@gu.seFöretagGöteborgs universitet
AdressGöteborgs universitet
Box 100
40530 GÖTEBORG
Övriga kontaktuppgifterTelefonnummer: 031-7860000
Jobbnummer 1605597
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