Formulation Senior Scientist - Advanced Drug Delivery
AstraZeneca AB / Kemiingenjörsjobb / Göteborg
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hela Sverige At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.
Pharmaceutical Sciences at AstraZeneca deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans traditional small molecules, peptides, oligonucleotides to RNA based therapeutics across AstraZeneca's therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to provide novel products to AstraZeneca's clinical pipeline.
We now seek a talented, motivated Formulation Senior scientist to join our team in Gothenburg, Sweden. It is a key scientific position that will lead formulation and delivery evaluation from discovery to clinical candidate nomination. The focus is the new modality and advanced drug delivery portfolio of oligonucleotides, RNA and peptides-based therapeutics. You will be reporting to the team leader for CMC Formulation and collaborate closely with other ADD teams located in Waltham, US, Cambridge, UK and Gothenburg, Sweden.
Main Duties and Responsibilities
* Evaluate and develop formulations, delivery systems, and analytical methods for biomolecules with a focus on peptides.
* Lead or support the production of drug products for non-GxP studies and for GMP manufacturing.
* Work flexibly in preclinical and clinical CMC (Chemistry, Manufacturing, and Control).
* Represent the department in the CMC team. Align activities with other functions including drug substance, drug product, quality control, quality assurance, and supply chain, device, and regulatory for CMC team in clinical phase.
* For projects in pre-clinical stage, represent Pharmaceutical sciences and align activities with chemistry, biology, clinical, and preclinical representatives to develop the project strategy.
* Evaluate and lead outsourcing activities. This should be sufficient.Engage in external technology evaluations in collaboration
* Work as a member of cross-functional pharmaceutical project teams, with a large degree of independence representing own group and area of expertise.
* Develop expertise in a scientific skill discipline and continue to demonstrate scientific scholarship.
* Remain up to date with relevant internal and external developments that affect the company and function and share with other members of team or function.
* Ensure that own work and the work of others is performed in accordance with appropriate Safety, Health & Environment (SHE), quality, and compliance standards.
Essential Requirements
* MSc degree in a relevant scientific discipline (e.g., Biochemistry, Pharmaceutics, Biotechnology, Biophysics, or Chemistry)
* Experience developing different administration routes and formulation technologies to enable formulation development and influencing drug product design including parenteral, oral and inhaled delivery of biologics.
* Knowledge of analytical characterization of biomolecules (e.g. H/UPLC, CE, particulate/aggregate analysis, DSC, ITC, fluorescence and scattering)
* Experience working with biomolecules (e.g., peptides or proteins) and the desire to explore new modalities
* Ability to communicate and write proficiently in English.
Desirable Requirements
* Ph.D. degree in a relevant scientific discipline (e.g., Biochemistry, Pharmaceutics, Biotechnology, Biophysics, or Chemistry)
* 1-3 years of work experience in industry focusing on formulation development, biophysical or analytical characterization of proteins and peptide and/or delivery systems.
* Exposure to multiple disciplines in Drug Discovery, Pharmaceutical Sciences, and related functions.
If you are interested, apply now!
We will screen candidates continuously and we need your application at the latest February 16, 2020.
For more information about the role please contact Sara Richardson, Team Leader Advanced Drug Delivery +46725821650
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2020-01-21ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2020-02-04
Klicka på denna länk för att göra din ansökanFöretagAstrazeneca AB
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-072063".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Jobbnummer 5051998
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