Doktorander/utbildningsplats
Sahlgrenska akademin vid Göteborgs universitet / Apotekarjobb / Göteborg
2011-05-10
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U 2011/305
The role of neonatal adaptive immunity in the encephalopathy of prematurity
Application deadline: 2011-05-31
Description of the research project
Preterm birth is becoming a more common and serious problem in modern society. Brain injury in the premature infant, particularly the infant of very low birth weight, is a problem of major importance. The encephalopathy of prematurity, the most common form of injury to the preterm brain, is generally thought to consist primarily of periventricular leukomalacia, a distinctive form of cerebral white matter injury. It is characterized by loss of premyelinating oligodendrocytes, and is associated with a high risk of neurodevelopment impairment, such as spastic motor deficits categorized as cerebral palsy, and /or cognitive/attentional/behavioral/socialization defects that significantly impair quality of life. Currently, the mechanisms of premyelinating oligodendrocytes injury in periventricular leukomalacia are unclear.
The current project will focus on the role of neonatal adaptive immunity in the encephalopathy of prematurity. The project is highly innovative and will help to gain new insights for understanding the pathogenesis of encephalopathy of prematurity and leading to the discovery of new prevention/neurprotective strategies. The study includes several distinct but closely related projects that will study different aspects of neonatal adaptive immunity in relationship with the encephalopathy of prematurity; with focuses on the impact of brain antigen to neonatal brain injury and the underlying cellular mechanisms; the role of some highly up-regulated inflammatory regulators in these process; as well as the role of these inflammatory regulators mediated T cell subsets balance in the preterm newborn brain injury process. The project represents an international collaboration with Dana-Farber Cancer Institute and Harvard Medical School.
Desired background
We welcome applicants that are highly motivated, with an interest in perinatal brain injury. It is desirable that the candidate has a background in immunology and/or molecular biology.
For more information about the project, please contact main supervisor Xiaoyang Wang, Institute of Neuroscience and Physiology, e-mail:
xiaoyang.wang@fysiologi.gu.se , phone: +46 31 786 3260.
Publiceringsdatum2011-05-10Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
Så ansöker duSista dag att ansöka är 2011-05-31
Ange följande referens när du ansöker: "Ref nr U 2011/305"
Ansökan kan tyvärr inte göras via e-post.
FöretagSahlgrenska akademin vid Göteborgs universitet
AdressSahlgrenska akademin vid Göteborgs universitet
Box 400
40530 GÖTEBORG
KontorsadressMedicinaregatan 3
KontaktuppgifterTelefonnummer: 031-7860000
Jobbnummer 928997
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