Disease Area Expert
AstraZeneca Mölndal / Biologjobb / Mölndal
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hela Sverige Respiratory & Inflammation iMed Translational Science - Disease Area Expert (Translational Medicine)
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
Description
As part of the Translational Science (TS) Leadership Team the role holder ensures effective Translational Science input to the R&I Disease Area Strategy anchored in clinical experience and understanding of patient needs. As operational leader she/he drives implementation of this strategy on the level of target generation, patient selection and development and execution of translational science plans including hypothesis testing in a clinical setting (Experimental medicine). The aim is to ensure a clear path from Target Selection to clinical Proof of Concept including line-of-sight biomarker strategies so that patient needs can be effectively translated into a viable project portfolio.
The role responsibilities require profound understanding of the respiratory and inflammation therapeutic area with special emphasis on immunity. The ability to mediate close interactions and collaboration between Discovery and Clinical is essential.
Accountabilities & Responsibilities
Guides the implementation of the R&I Disease Area strategy on the level of Target Selection.
Coordinates the development of the Translational science plans for the Disease Area and projects involving relevant expertise from other functions in as required.
Fosters a culture of line-of-sight biomarker thinking, with biomarker plans including biomarkers for patient stratification, target occupancy, target mechanism, physiological response, pathophysiology and clinical outcome initiated already at Target Selection.
Guides the development and delivery (from animal to man) of clinically qualified biomarkers to support dose selection/scheduling, go/no go decision-making, patient stratification/selection at disease area as well as project level.
Identifies, develops and timely delivers suitable pharmacodynamic efficacy biomarkers for targets/projects to better inform and clarify our decision making during early development
Ensures that all nominated biomarkers are fit for purpose in the clinical environment
Works in collaboration with the safety organization, to deliver suitable toxicology biomarkers for research programs
Works with clinical leads and project team leads, to ensure smooth implementation and execution of all biomarker plans
Identifies exploratory biomarkers relevant for disease progression and/or patient stratification working in collaboration with PHB and additional internal and external collaborators that can be tested and subsequently validated
Works with Clinical leaders to execute the clinical biomarker plans..........
for FULL JOBDECRIPTION and to apply please visit:
www.astrazeneca.se. Ref nr MOL000000XW
Publiceringsdatum2013-05-16Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2013-05-30
Ange följande referens när du ansöker: MOL000000XW
Ansökan kan tyvärr inte göras via e-post.
FöretagAstraZeneca Mölndal
AdressAstraZeneca Mölndal
43183 MÖLNDAL
KontorsadressPEPPAREDSLEDEN 1
MÖLNDAL
Övriga kontaktuppgifterTelefonnummer: 031-7761000
Jobbnummer 1554798
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