PostDoc Fellow - The impact of metabolic disease in vivo on
AstraZeneca Göteborg / Apotekarjobb / Mölndal
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hela Sverige PostDoc Fellow - The impact of metabolic disease in vivo on human ß-cell health
As a world leader in cardiovascular and metabolic medicines, we're always working on innovative new drugs that will change lives across the globe. To make that happen, we've divided our small molecule research strategy into three priorities: cardiac regeneration, islet health in diabetes and diabetic nephropathy. You'll focus your efforts on making real progress toward slowing, stopping or curing some of the most aggressive diseases that face humanity today.
Main duties and responsibilities
PostDoc long title: Human ß-cell dedifferentiation versus apoptosis during prolonged metabolic stress in vivo - transcriptomic and functional studies.
We have an exciting opportunity for a highly motivated PhD to explore the role of beta-cell apoptosis versus dedifferentiation in diabetes. You'll study beta-cell gene expression signatures in controlled in vivo models of diabetes to define the transcriptome of beta-cells under metabolic stress in vivo. Specifically, you'll identify and experimentally validate key genes that drive phenotypic beta-cell change to an apoptotic or dedifferentiated and dysfunctional beta-cell, utilising a unique tool developed by AstraZeneca to facilitate complex transcriptomic analyses.
Key responsibilities will be to transplant beta-cells under the kidney capsule of mice and monitor metabolic phenotype of the recipients with standard tests such as glucose tolerance tests, and perform RNA-Seq based transcriptomic analyses. You'll culture cell lines like Min6cl4 and EndoC, isolate and culture beta-cells from primary mouse and human tissue, and culture and differentiate iPS derived beta-cells. Designing, performing and evaluating knock down and over-expression experiments in cell lines, and performing functional islet studies will form part of the role.
With access to state-of-the-art technology platforms, you'll collaborate with excellent AstraZeneca scientists across many disciplines, as well as external collaborators, primarily at Harvard University. We'll encourage you to communicate results and novel findings at conferences and publish scientific papers in high-ranked journals.
Essential requirements
PhD and/or MD in cell and molecular biology, biochemistry or physiology
Good cell and molecular biology lab skills (e.g. cell culture, imaging, cell sorting, transfection, western blotting, qPCR)
Solid experience in biology relevant to diabetes
Scientific track record in islet biology and specifically in beta-cell function
Experience in performing animal studies (e.g. GTT, islet transplantations)
Bioinformatics skills
A strong scientific track record, evidenced by published papers in peer-reviewed journals
Ability to work independently but collaboratively and generate hypotheses based on experimental data in a focused manner.
At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you'll develop further and faster than you thought possible. We'll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expertise and build your skills. So if you're curious about what science can do, come and make a difference.
As a world leader in cardiovascular and metabolic medicines, we're always working on innovative new drugs that will change lives across the globe. To make that happen, we've divided our small molecule research strategy into three priorities: cardiac regeneration, islet health in diabetes and diabetic nephropathy. You'll focus your efforts on making real progress toward slowing, stopping or curing some of the most aggressive diseases that face humanity today.
Publiceringsdatum2017-02-27Så ansöker duSista dag att ansöka är 2017-04-17
Klicka på denna länk för att göra din ansökanFöretagAstraZeneca Göteborg
AdressAstraZeneca Göteborg
Pepparedsleden 1
43183 MÖLNDAL
KontorsadressPepparedsleden 1
Jobbnummer 3343286
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