PostDoc Fellow - Cytokine mediated gene regulatory networks
AstraZeneca Göteborg / Apotekarjobb / Mölndal
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hela Sverige PostDoc Fellow - Cytokine mediated gene regulatory networks in the control of Th17 cell plasticity in health and disease.
At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you'll develop further and faster than you thought possible. We'll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expertise and build your skills. So if you're curious about what science can do, come and make a difference.
Our Respiratory, Inflammation and Autoimmunity team offers definitive expertise to colleagues across the business. You'll help patients in areas with medical needs that aren't being fully met, including chronic obstructive pulmonary disease, asthma and rheumatic disorders. Right now, we're a leading figure in inhaled drug development, and our new Inhalation Centre in Gothenburg, Sweden is set to extend that lead even further.
Main duties and responsibilities
This is an outstanding opportunity to learn a range of new techniques while conducting cutting-edge research using unique in-house generated tools. Joining a basic and translational research team focused on understanding T cell plasticity in health and disease, you'll lead the mechanistic investigation of cytokine-induced signaling pathways in the maintenance and regulation of pathogenic and non-pathogenic Th17 cell plasticity. An integrated approach utilising transcriptomics, ChIP-seq, and proteomics analysis, along with well-defined cell culture and disease models, it is expected to unravel mechanistic insight into functional plasticity of Th17 cells.
You'll plan, perform and interpret independent research projects focused on the isolation of primary human T cell subsets from the whole blood. As well as building expertise in RNA-Seq, ChIP-seq and other cutting edge NGS technologies, you'll develop and perform genetic manipulation techniques, including use of gene editing approach related to functional analysis of key elements related to cell plasticity. Validation of hypothesis in pre-clinical animal disease model will also be part of your role.
You'll work closely with our academic collaborators, including Dr. Arian Lawrence (Newcastle University, UK) and Dr. Kevin Maloy (University of Oxford) labs, and be encouraged to draft scientific papers for publication.
Essential requirements
PhD and/or MD in immunology, solid knowledge of T cells immunology and at least one first author publication in a high quality scientific journal
Skills relating to primary T cell cultures, mouse models, flow cytometry, cell sorting, siRNA mediated knock down, ELISA and immunological in-vitro assays
Oral and written communication skills in English
Highly motivated and able to work independently and as a team player
Desire to unfold your high potential in an international collaborative research.
Desirable requirements
Experience with standard molecular biology/cloning techniques and methods for transient and stable gene transfer using viral vectors and electroporation
Knowledge around Th17 cell biology, gene editing technology and next generation sequencing
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
This is a 2 year Fixed Term Contract opportunity, plus 1 year which will be merit based. The role will be based at Gothenburg, Sweden with a competitive salary on offer
At AstraZeneca, we believe in the potential of people who share our passion for science. By thinking boldly and working collaboratively to pursue discoveries beyond imagination, you'll develop further and faster than you thought possible. We'll complement your drive and determination to meet unmet patient needs around the world with the inspiration and opportunities to enhance your niche expertise and build your skills. So if you're curious about what science can do, come and make a difference.
As a world leader in cardiovascular and metabolic medicines, we're always working on innovative new drugs that will change lives across the globe. To make that happen, we've divided our small molecule research strategy into three priorities: cardiac regeneration, islet health in diabetes and diabetic nephropathy. You'll focus your efforts on making real progress toward slowing, stopping or curing some of the most aggressive diseases that face humanity today.
Publiceringsdatum2017-03-27Så ansöker duSista dag att ansöka är 2017-04-17
Klicka på denna länk för att göra din ansökanFöretagAstraZeneca Göteborg
AdressAstraZeneca Göteborg
Pepparedsleden 1
43183 MÖLNDAL
KontorsadressPepparedsleden 1
Jobbnummer 3399523
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