Postdoc Fellow - Augmented Exosomes for Cardiac Repair
AstraZeneca / Biomedicinjobb / Göteborg
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hela Sverige AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. We're proud to have a unique workplace culture that inspires innovation and collaboration. We believe in the potential of our people and you'll develop beyond what you thought possible.
The new R&D BioPharmaceuticals organisation brings together research and development teams, from discovery through to late-stage development for Cardiovascular, Renal & Metabolic (CVRM), Respiratory, Inflammatory and Autoimmune (RIA) therapy areas, and opportunistically for Microbial Sciences and Neuroscience.
You'll be in a global pharmaceutical environment but also exposed to strong rigorous academic science. For example, every postdoc has an external academic mentor to ensure we are working and publishing at the highest level in a field. What's more, you'll have the support of a leading academic advisor, who'll provide you with the guidance and knowledge you need to develop your career.
We are looking for a highly motivated individual to work with and explore extracellular vesicles as a regenerative therapy for treatment of heart failure. Extracellular vesicles represent an exciting opportunity for a cell-free approach to achieve cardiac repair and is an opportunity for delivery of complex RNA-based drugs. We now have openings for three new postdocs working in this area 1) exploring the action and underlying biological mechanisms of engineered extracellular vesicles in a therapeutic setting (this position in CVRM) 2+3) extracellular vesicles for delivery of mRNA and targeting to heart (separate recruitment in Discovery Sciences).
Accountabilities and Responsibilities;
Myocardial infarction (MI) results in severe damage to the heart muscle tissue with scar formation and irreversible loss of cardiac function that will lead to development of heart failure. Encouraging results have been achieved with cell therapy to repair the heart tissue and improve function, but there is accumulating evidence that these beneficial effects are mediated by extracellular vesicles.
You'll study the action of engineered extracellular vesicles from various cardiac cell types in in vitro assays relevant for cardiac repair and in rodent heart failure models. You'll also explore gel patches for improved retention after intramyocardial delivery and apply the latest transcriptomics and proteomics approaches to identify specific factors in extracellular vesicles that drive the desired biological phenotype.
You'll work closely with postdoc colleagues in Discovery sciences who will focus on engineering extracellular vesicles for the in vitro and in vivo studies. You'll have the opportunity to conduct independent cutting-edge work in state-of-the-art laboratories while teaming with other AZ scientists. We'll support development of leadership skills and deeper understanding of drug development process.
Main Accountabilities and Responsibilities:
* Independently design, develop and execute in vitro and in vivo experiments
* Independently analyse and interpret generated data
* Maintain deep understanding of the science in heart failure and cardiovascular area
* Presentation of data at internal and external meetings
* Communications of scientific findings through publications in world class scientific journals
* Contribute proactively to a vibrant and innovative working environment
Education and Experience required:
Essential:
* PhD in cardiovascular disease
* A strong scientific track record in any of the following fields: regenerative medicine, cardiovascular disease, heart failure or extracellular vesicles, as evidenced by published papers in high quality peer-reviewed journals.
* Proven ability to independently design and execute experiments and interpret results
* Strong collaboration skills
* Strong oral and written communication skills
* Hands on experience in handling relevant iPS cells and primary human cardiac cell types
* Experience in performing relevant in vitro assays within the cardiovascular area
* Expertise in cell and molecular biology, imaging and transcriptomics and/or proteomics
* Experience to work in vivo such as general animal handling and blood sampling, or an interest to learn in vivo work
Desirable:
* Working experience of isolation and characterization of extracellular vesicles
* Experience with performing myocardial infarction in rodents and intramyocardial injections
* Experience with cardiac targeting and biodistribution
* Experience in drug delivery
This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1-year extension which will be merit based. The roles will be based in Gothenburg, SE, with a competitive salary on offer. To apply for this position, please click the apply link below.
Advert opening date - 31st May 2019 / Advert closing date - 9th August 201
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
Varaktighet, arbetstid
Heltid Temporary
Publiceringsdatum2019-06-03ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2019-06-20
Ange följande referens när du ansöker: R-046179
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca UK
Emma.wood@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparedsleden 1
Jobbnummer 4816087
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