Computational chemist
Karolinska Institutet, Institutionen för medicinsk biokemi och b / Kemistjobb / Stockholm
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Division
Within the Division of Translational Medicine and Chemical Biology (Helleday laboratory), Department of Medical Biochemistry and Biophysics, Karolinska Institutet, the physical location will be at Science for Life Laboratory (SciLifeLab) Stockholm.
Our vision, within the Helleday Laboratory, is to translate the findings from our basic research programmes on DNA repair and survival mechanisms within cancer cells, to identification of novel anticancer targets and development of anti-cancer drugs with minimal side-effects.
Our goal is to develop our hypotheses in preclinical models, and then proceed to study the effect and underlying mechanisms of new cancer treatments in patients. In order to do this, we have created an integrated translational strategy, with teams of scientists from a variety of disciplines taking our basic findings all the way from bench to bedside.
We are working in a dynamic research environment, which is well positioned to take advantage of the state-of-the-art platforms at SciLifeLab, we have several established and fruitful collaborations with Stockholm and Uppsala universities and many of our researchers have experience both from academia and the pharmaceutical industry. We are based at SciLifeLab, Karolinska Institutet, where we perform high-throughput screening, basic molecular and cell biology, biochemistry, systems biology, pharmacology and medicinal chemistry.
Today the research group consists of around 30 people. We now wish to expand this number with another 8-10 scientists to meet the ambitious milestones we have set for the next few years.
For a more comprehensive description of our different projects and an overview of our group, please visit our website
www.helleday.orgDuties & Entry requirements
The molecular modeler will support the medicinal chemistry team in the design and synthesis of novel anti-cancer compounds. The duties will involve modeling of ligand-protein interactions and generation of SAR data and binding hypotheses.
You have a strong background in molecular modeling with experience in both ligand-based and structure-based molecular methods and you will probably have completed a Ph.D. in this area. You are used to modeling ligand-protein interactions, development of QSAR models, and are well oriented in the areas of docking and virtual screening. Experience of working in collaboration with medicinal chemists, crystallographers and molecular biologists is highly desirable and therefore a good understanding of organic chemistry and structural biology is required. Past experience of database administration would also be of merit.
Eligible applicants will have a well-documented track record of relevance to the employment. The successful candidate will need a strong passion for daily experimental work and an aptitude for analysing, managing, interpreting and reporting data to the project team. The work will be performed in multidisciplinary and multicultural project teams and in close collaboration with other academic research groups and clinicians in Sweden. The ability to communicate well in English (both oral and written) is therefore highly desirable. In addition to actively participating in research projects, some teaching may be required. The successful candidates should have excellent interpersonal and cooperation skills, be flexible and be capable of working in a structured and efficient way. The successful candidates should also be able to contribute to the innovative and entrepreneurial climate existing within the group.
Karolinska Institutet promotes equality and values the qualities that ethnic and cultural diversity can bring to the university.
Employment form: two year project employment, with potential to be prolonged.
Application process
The application is to be submitted on the NetRecruiter system.
Karolinska Institutet är ett av världens ledande medicinska universitet. I Sverige står Karolinska Institutet för drygt 40 procent av den medicinska akademiska forskningen och har det största utbudet av medicinska utbildningar. Sedan 1901 utser Nobelförsamlingen vid Karolinska Institutet mottagare av Nobelpriset i fysiologi eller medicin.
Enligt Riksarkivets föreskrifter arkiveras ansökningshandlingar i två år efter att tillsättningsbeslutet vunnit laga kraft. Detta gäller dock ej bilagor som är tryckta eller på annat sätt publicerade.
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Publiceringsdatum2012-11-06Arbetstider och omfattning100 % visstidsanställning till 2014-12-31
Så ansöker duSista dag att ansöka är 2012-11-30
Ange följande referens när du ansöker: 6590/2012
Ansökan kan tyvärr inte göras via e-post.
Klicka på denna länk för att göra din ansökanKontaktProject Leader Ulrika Warpman Berglund, +46 8 524 815 64
Research Manager Kristina Edfeldt, +46 8 524 81569
Facklig kontaktAnna Aleman, OFR, 08-524 866 07
Biborka Bereczky Veress, SACO, 46 70-173 85 75
Gunnar Stenberg, SEKO, 08-524 880 75
FöretagKarolinska Institutet, Institutionen för medicinsk biokemi och biofysik
AdressKarolinska Institutet, Institutionen för medicinsk biokemi och biofysik
Karolinska Institutet
17177 Stockholm
Jobbnummer 1384299
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