Senior Biotransformation Scientist
AstraZeneca / Apotekarjobb / Göteborg
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hela Sverige Do you have expertise in biotransformation and mass spectrometry? Would you like to apply your expertise in a company that is following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!
We are now recruiting a Senior Biotransformation Scientist to join the Drug, Metabolism and Pharmacokinetics (DMPK) department within the Cardiovascular, Renal and Metabolism (CVRM) therapeutic area. We are looking to complement the Drug Metabolism and Disposition team and expand our capability regarding biotransformation of peptide and oligonucleotide drugs. The position is placed in Gothenburg, Sweden.
CVRM is one of the three main therapeutic research areas within Innovative Medicines and Early Development (IMED) which deliver candidate drugs into clinical development. CVRM is based in AstraZeneca's world-class vibrant R&D center, located in Gothenburg, Sweden. DMPK interacts with other functions in supporting CVRM projects along the value chain, from target selection all the way to launch and life cycle management.
As a Senior Biotransformation Scientist you will be part of a team at the forefront of DMPK science focusing on the biological fate of molecules in preclinical species and humans.
We look to you to act as an expert in your area providing proficient scientific advice on drug disposition to project teams. This is a lab-based leadership role, which main task will be to study and elucidate mechanisms and pathways that determine metabolism and disposition of drug substances. You are responsible for metabolite profiling and identification of small molecule and new modality (e.g. peptide and oligonucleotide) drug metabolites in biological samples. With your hands-on biotransformation and LCMS-analysis experience, you are expected to develop and implement novel approaches and will provide significant input for a broad range of drug modalities to projects, from target identification to life-cycle management. The career level of the position will depend on the experience of the successful candidate.
In this role, you will have the opportunity to contribute to the discovery of new life-changing medicines for patients and demonstrate and witness what science can do.
Essential requirements
* PhD degree or equivalent qualification, and at least five years' experience relevant to the position
* Background in analytical chemistry, medicinal chemistry or biochemistry.
* In-depth experience of high resolution accurate mass spectrometry (MS), including competence to handle small molecules and/or drug candidates beyond small molecules, such as peptides, proteins and/or oligonucleotide-based drugs
* Excellent knowledge of sample preparation of biofluids, liquid chromatography and mass spectrometry, technical skills to operate and perform regular maintenance and elementary trouble shooting
* Expert in structure elucidation of metabolites, with basic understanding of the mechanisms of P-450 oxidations/reactive metabolites and how this may influence drug design
* Basic understanding of the enzymology of drug metabolism
* Scientific leadership, evidenced by a publication track record
* Excellent communication skills in English, both verbal and in writing
* Excellent interpersonal skills
* Knowledge of guidelines and policies in drug development regarding biotransformation, including MIST
* Experience from industry environment a plus, but not mandatory.
This is an exciting opportunity for a talented biotransformation scientist to join a strong team at the forefront of DMPK science, to innovate and support the portfolio of a major pharmaceutical company that has science at its heart and a tremendously strong pipeline whilst being based in the wonderful city of Gothenburg, Sweden.
If you are interested, apply now!
For more information about the position please contact hiring manager Constanze Hilgendorf,
Welcome with your application no later than November 25, 2018.
AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2018-10-24ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2018-11-21
Ange följande referens när du ansöker: R-037880
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
ulrica.marklund1@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparedsleden 1
Jobbnummer 4421197
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