PostDoc Fellow - C-H bond activation catalysis for selective ami

AstraZeneca Göteborg / Apotekarjobb / Mölndal
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PostDoc Fellow - C-H bond activation catalysis for selective amination reactions.

Main duties and responsibilities

PostDoc long title: Metal-catalyzed C-H bond activation, allowing for selective amination reactions. Late stage functionalization of drug-like substrates

This is an excellent opportunity within the Medicinal Chemistry department of CVMD to broaden your skills in both synthetic organic chemistry and organometallic chemistry in a creative drug discovery scientific environment. You'll be part of the Excellence in Synthesis/Automation team - a vibrant and multicultural group focused on integrating chemical technology and automation to challenging strategic medicinal chemistry.

You'll be guided and coached by scientists at AstraZeneca in Gothenburg, Sweden, and have the opportunity to collaborate with, and be mentored by, Dr. Abraham Mendoza at Stockholm University.

The role will focus on strengthening metal catalysis skills at the interface between small molecule synthesis and medicinal chemistry, in an industrial setting. You'll develop synthetic methodologies for synthesis of new catalytic systems useful in LSF and for C-H aminations in batch, flow and high-throughput. You'll also be responsible for the application of the prepared building blocks and generation a toolbox of structurally novel elements to be used in medicinal chemistry. This will see you working collaboratively with scientists from across multiple disciplines, both internally and externally, performing research independently and communicating your results both within AstraZeneca via global working groups and externally at scientific meetings and through high impact publications.

Essential requirements:
PhD and/or MD in synthetic organic chemistry and/or medicinal chemistry
Solid background in classic organic chemistry, highly-rigorous inert techniques, purification and structural elucidation techniques
In-depth knowledge and understanding in late stage functionalization reactions, focusing on CH activation catalysis
Strong organisational and interpersonal skills
An outstanding track record of research, proven by high impact publications in peer reviewed journals, patents and/ or talks at scientific meetings.

Desirable requirements:
Expertise in late stage functionalisation techniques and/or inorganic synthesis
Hands-on experience of organometallic chemistry
Proven track record of problem solving and delivery in organic chemistry/medicinal chemistry
Previous post doc experience
Pronounced ability to work in multidisciplinary teams, high levels of collaboration and communication.

At AstraZeneca we believe in the potential of our people and you'll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve. We need great people who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world. If you're curious about what science can do, then you're our kind of person.

As a world leader in cardiovascular and metabolic medicines, we're always working on innovative new drugs that will change lives across the globe. To make that happen, we've divided our small molecule research strategy into three priorities: cardiac regeneration, islet health in diabetes and diabetic nephropathy. You'll focus your efforts on making real progress toward slowing, stopping or curing some of the most aggressive diseases that face humanity today.

Publiceringsdatum
2017-02-25

Så ansöker du
Sista dag att ansöka är 2017-04-17
Klicka på denna länk för att göra din ansökan

Företag
AstraZeneca Göteborg

Adress
AstraZeneca Göteborg
Pepparedsleden 1
43183 MÖLNDAL

Kontorsadress
Pepparedsleden 1

Jobbnummer
3341845

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