PhD student position in medical science - Role of proteoglycans
Göteborgs universitet / Administratörsjobb (offentlig verksamhet) / Göteborg
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hela Sverige Publiceringsdatum2015-10-28Beskrivning av verksamhetenThe University of Gothenburg tackles society's challenges with diverse knowledge. 37 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.
Dina arbetsuppgifterType of employment: Fixed-term employment, 4 år Extent: 100 % Location: Sahlgrenska Academy, Gothenburg First day of employment: As agreed Reference number: UR 2015/902 Project title: Diabetes mellitus and beta cell failure: the role of proteoglycans in the pathogenesis of Type-1 and Type-2 diabetes Job assignments: Diabetes mellitus may be characterized as an insufficiency of the pancreas to produce insulin (T1D) or an incapacity of the peripheral tissue to respond to the insulin (T2D). An important but less recognized aspect is that both patient groups experience a loss of beta cells in the islands of Langerhans. While subjects with T1D experience a loss due to an autoimmune reaction, the beta cell failure in T2D is caused by the deposition of islet amyloid polypeptide (IAPP) in the islets, in a mechanism similar to that of Aß-induced cell death in Alzheimer's disease. The mechanism(s) responsible for the selective destruction of the beta cells in T1D and T2D remains largely unknown. While there have been significant advances in the fields of genomics and proteomics to support our understanding of differential gene and protein expression in these diseases, glycosylation and its influence on beta cell loss have remained relatively unexplored, despite indications that these protein modifications might have fundamental impacts on the disease processes. Proteoglycans (PGs) are complex molecules present in all tissues and composed of a protein core, to which heparan sulfate (HS) - or chondroitin sulfate (CS) side chains are attached. PGs accelerate the pathogenic process of islet amyloid deposition. In addition, prohormones of secretory granules often carry CS and the prohormones also serve as auto-antigens in T1D. Although purified fractions from secretory granules are effective in inducing the activation of diabetogenic T lymphocytes, synthetic prohormone-derived peptides are much less immune-provocative, suggesting a role for post-translational modifications. We therefore hypothesise that CS-glycopeptides derived from prohormones may serve as auto-antigens and thereby induce T cell activity in T1D. With our recent methodological advances in structural analysis and measurements of T cell response, we have now unique possibilities to investigate completely novel aspects of beta cell failure in diabetic patients and animal m odels. The project relies on the combination of expertise in glycobiology and immunology to measure immune responses to glycopeptides, which gives the project a unique profile and platform for success. We would like the applicants to motivate why they interested in the project and why they are suitable applicants.The PhD position comprises 4 years full-time studies and leads to a doctoral degree. The position is funded via doctoral studentship.
Utbildning och erfarenhetTo be admitted to third-cycle studies you must fulfill both the general and the specific entry requirements. The general entry requirements is fulfilled if you have: 1. completed a degree at a second-cycle level, or 2. completed at least 240 credits worth of studies of which at least 60 credits must be at a second-cycle level, or 3. acquired equivalent knowledge in some other way in Sweden or abroad. The specific entry requirements is fulfilled if you have completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.
Varaktighet, arbetstid
Visstidsanställning 6 månader eller längre
Heltid
TillträdeAs agreed
ErsättningFast månads- vecko- eller timlön
Så ansöker duSista dag att ansöka är 2015-11-23
Appointment procedure: Please apply online at the University of Gothenburg job application portal:
Klicka på denna länk för att göra din ansökanKontaktGöran Larson, Institute of Biomedicine, Project supervisor, 031-786 0000
goran.larson@clinchem.gu.seFöretagGöteborgs universitet
AdressGöteborgs universitet
Box 100
40530 GÖTEBORG
KontorsadressVasagatan 33
Övriga kontaktuppgifterTelefonnummer: 031-7860000
Jobbnummer 2501762
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