PhD position in medical science-How do GLP-1 analogues alleviate
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Workplace; Sahlgrenska Academy, Gothenburg
Profession: PhD position in medical science-How do GLP-1 analogues alleviate obesity?
Reference number: UR 2016/240. Project title: Glucagon-like peptide-1 (GLP-1) suppresses body fat mass via interleukin-6 (IL-6) in the brain: How and where? Job assignments: Obesity is a growing health problem with few good pharmacologic treatments at present. Our research group was first to show that the cytokines interleukin-6 (IL-6) and IL-1 in the brain exert an inhibitory effect on body fat during health (Wallenius V et al Nat Med 8:75-79, 2002, cited 950 times; Garcia M et al Diabetes 55:1205-1213, 2006, cited 134 times). These finding were unexpected, as it had been assumed that the major biological effect of IL-6 and IL-1 is to stimulate immune function. Recently, we found that the pharmacological group of GLP-1 analogues exerts its well known anti-obesity effect by increasing the expression of brain IL-6 and IL-1 (Shirazi R et al PNAS 110:16199-16204, 2013). As GLP-1 analogues also alleviate type 2 diabetes, they are increasingly used all over the world. The major aim of the project is to investigate how and where in the brain GLP-1 inhibits food intake and body fat via IL-6 and IL-1. Understanding the me chanism of action of a successful obesity treatment like GLP-1 analogues, is likely to provide the pharmaceutical industry with new and more refined treatments of obesity. The project includes work with genetically modified mice. There will be extensive studies of brain anatomy using immunohistochemistry and newly generated reporter mice. The in vivo work includes precision surgery with injections into specific parts of brain to perform site-specific knockdown of IL-6 receptor. Brains of mice will be further studied by confocal microscopy as well as gene expression analysis, using laser capture technique to isolate tissues. The PhD project will be performed at the Endocrine unit at the Physiology department with access to laboratories, equipment and methods to do immunohistochemistry, protein analysis and gene expression analysis. There will collaboration with excellent research groups in Gothenburg as well as internationally.
Eligibility: To be admitted to third-cycle studies you must fulfill both the general and the specific entry requirements. The general entry requirements is fulfilled if you have: 1. completed a degree at a second-cycle level, or 2. completed at least 240 credits worth of studies of which at least 60 credits must be at a second-cycle level, or 3. acquired equivalent knowledge in some other way in Sweden or abroad. The specific entry requirements is fulfilled if you have completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.
Appointment procedure: Please apply online at the University of Gothenburg job application portal:
http://www.gu.se/omuniversitetet/aktuellt/ledigaanstallningar/Varaktighet, arbetstid
Tillsvidare
Heltid
Start as agreed Fixed-term employment, 4 years
Publiceringsdatum2016-04-22ErsättningFast månads- vecko- eller timlön
KontaktProject supervisor John-Olov Jansson +46 31 786 00 00
joj@medic.gu.seFöretagGöteborgs universitet
AdressGöteborgs universitet
Box 100
40530 GÖTEBORG
KontorsadressUniversitetsplatsen 1
Övriga kontaktuppgifterTelefonnummer: 031-7860000
Jobbnummer 2799927
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