Synthetic Chemists With Focus On Protac's
AstraZeneca / Logistikjobb / Göteborg
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hela Sverige Do you have the ambition to be an industry leading drug hunter?
AstraZeneca now offer exciting opportunities for individuals with great skills in synthetic organic chemistry and a special interest in bridging novel synthetic chemistry and medicinal chemistry into design and synthesis of PROteolysis Targeting Chimeras (PROTACs). As part of an open minded, creative and experienced team, you will contribute with your high ambitions and enthusiasm to push the boundaries of science in the area of targeted protein degradation. The positions are placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.
Cardiovascular, Renal and Metabolism (CVRM) is one of AstraZeneca 's core therapy areas. We follow the science and turn ideas into life changing medicines for patients suffering from Heart Failure, Diabetes or Chronic Kidney Disease. We drive our pipeline and areas of scientific leadership internally and in collaborations with world experts which provides you as a scientist with the unique opportunity to access the most advanced knowledge and opportunities to stay at the fore-front of science.
The CVRM Medicinal Chemistry Department is a critical player in the discovery and design of drug molecules to identify and validate novel biological targets. We are proud of our successful delivery of clinical candidates to human testing leading to new medicines for patients. To realize our ambitions, we stay agnostic to molecular modality and we are now further expanding our efforts in the area of targeted protein degradation and PROTAC's.
Main duties and responsibilities
We are now growing our capabilities in the area of targeted protein degradation and as a synthetic chemist you will play a key role in expanding and progressing the PROTAC's modality science within CVRM and AstraZeneca. The role is lab based and focused in the area of medicinal chemistry with emphasis on synthetic chemistry and in particular PROTAC synthesis and design. You will actively contribute to AstraZeneca drug portfolio projects by compound design and synthesis, data generation and data interpretation. The work is done in in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, DMPK and Pharmaceutical Sciences departments.
There will also be opportunities to develop medicinal chemistry, drug discovery and leadership experience together with the experts in the department. In addition, you are expected to be part of external collaborations, publish scientific papers, present and represent the department at conferences etc.
The career level of the role will be adjusted according to your level of experience.
Requirements
We are looking for communicative and ambitious individual that have expert knowledge in synthetic organic chemistry. Basic knowledge in medicinal from drug discovery in an industrial setting and/or the PROTAC-modality
* Ph. D. degree in Organic Chemistry or Medicinal Chemistry. Relevant post-doctoral experience in academic or industrial setting is an advantage.
* Synthetic chemistry: ability to plan, prioritize and perform work independently including synthetic route design and problem solving
* Scientific creativity: ability to identify, develop and apply new technologies and ways of working
* Excellent awareness of recent literature within synthesis/medicinal chemistry as well as current developments and trends in organic synthesis
* Highly self-motivated and capable of receiving and analyzing input from complex data and deciding on focused course of action
* Excellent teamwork, collaboration, networking and communication skills
* Ability to communicate your work both to senior chemistry leaders and in scientific papers and documents
If you are interested, apply now!
For more information about the position please contact recruiting manager Dr. Daniel Pettersen,
Welcome with your application no later than February 17th, 2019.
Please read more about AstraZeneca Gothenburg, the wonderful city of Gothenburg and life in Sweden at:
https://www.astrazeneca.com/our-science/gothenburg.htmlhttps://www.movetogothenburg.com/ AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2019-01-15ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2019-02-12
Ange följande referens när du ansöker: R-042859
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
ulrica.marklund1@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparedsleden 1
Jobbnummer 4557593
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