Senior Research Scientist - Genome Editing
Alten Sverige AB / Sjukhusteknikerjobb / Göteborg
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hela Sverige ALTENs Pharma-team in Gothenburg is searching for a motivated and competent Senior Research Scientist for a consultancy assignment at AstraZeneca.
About AstraZeneca:
AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. AstraZeneca is proud to offer a unique workplace culture that inspires innovation and collaboration. Co-workers are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity
The Arena:
The precise genome editing group is developing new tools and technologies to facilitate target validation, speedy disease modeling and to evaluate the potential applications and safety of therapeutic genome editing. We are part of the Translational Genomics department where we develop advanced cellular and animal models and we also provide expert support for Next Generation Sequencing and Transcriptome analysis. The candidate will be embedded in an international group working on cutting edge technologies with world leading external collaborators.
Tasks and responsibilities/The role:
• To design and build genome editing-based strategies and tools required to generate in vivo (mouse) and in vitro reagents to create disease models
• To develop delivery tools to improve the efficiency of in vivo genome editing
• To perform confirmation of genetic manipulation and functional validation of engineered animals
• To perform target validation studies in early projects
Minimum requirements:
• Molecular biology expertise on vector design and genetic manipulation of cell lines and/or mouse embryonic stem cells, primary and iPSC cells
• Functional characterization of gene modified cell lines
• In silico construct design and analysis of genetic perturbation after genome editing
Preferred experience and key factors:
• Generation and use of viral vectors (lentivirus, AAV, Adenovirus) and non-viral delivery tools for in vitro and in vivo delivery
• Previous practical expertise with genome editing tools including Cas9/CRISPR, ZFNs and TALENs
• Hands on experience with Next Generation Sequencing library preparation and results analysis
About ALTEN:
For over 20 years, ALTEN has developed its business by keeping to the core values ??that have built up the company's success. Every year, hundreds of ALTEN consultants have been given the opportunity to embark on challenging technical projects for our customers. ALTEN has a tradition of developing products in many areas, and history in Sweden is based primarily on skills in mechanics, software and electronics. Thanks to a successful concept in which we utilize the expertise of experienced consultants and develop young abilities towards a successful career, we have gained ground in many industries. Our Pharma initiative is based on the same successful concept with the same strong structure, but in a new exciting industry and a new field of expertise that includes knowledge in chemistry, biotechnology and biomedicine.
As an employee at ALTEN, we offer you a competitive salary based on your performance and work experience. You also have the opportunity to influence your assignments, different benefits and your overall working environment as well as choose your career path. We offer a wide range of internal trainings and an opportunity to plan for an international career. It is our conviction that genuine commitment is created through choice and the ability to influence your own personal development - our business model provides that opportunity. This freedom of choice enables us to offer our clients the most committed consultants, regardless of assignments. At ALTEN, we believe in growing together!
For questions about the position, please contact Rickard Westergren, Business Manager Pharma, at
rickard.westergren@alten.se.
Varaktighet, arbetstid
Heltid Tillsvidareanställning
Publiceringsdatum2018-04-09ErsättningEnligt överenskommelse
Så ansöker duSista dag att ansöka är 2018-04-15
Klicka på denna länk för att göra din ansökanKontaktHR-avdelningen, Alten
FöretagAlten Sverige AB
AdressAlten Sverige AB
Theres Svenssons gata 15
41755 Göteborg
KontorsadressTheres Svenssons gata 15, Göteborg
Jobbnummer 4071329
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