Role of peroxiredoxins aging budding yeast
Göteborgs universitet / Biologjobb / Göteborg
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hela Sverige The University of Gothenburg tackles society's challenges with diverse knowledge. 38 000 students and 6 000 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract scientists and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.
The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell - what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them.
At present, the institute has about 350 employees and approximately 290 million SEK in total assets.
Subject area
Role of peroxiredoxins in protein homeostasis and aging in budding yeast.
Subject area description
This project aims to decipher how yeast peroxiredoxin Tsa1 impinge on protein quality control, with special emphasis on aggregation of misfolded proteins, transport of protein aggregates to protein quality control compartments in the cells, and the asymmetrical inheritance of aggregates during cell division. Further, the project will analyze how cellular aging is affecting the activity of Tsa1 and how this, in turn, may influence the buildup of cytotoxic aggregates, including model disease proteins of human neurological disorders, during cellular aging.
Job assignments
The postdoctoral project consists of research and supervision. The research entails in-depth analysis of yeast redox signaling and protein aggregation using molecular, genetic, and biochemical tools. Microscopy including single-cell, as well as, ensemble analysis is a prominent part of the assignment. The project will also include the construction of new yeast strains suitable for microscopic analysis of protein aggregation and redox control.
Eligibility
An achieved doctoral degree is compulsory for a position as postdoctor at Göteborg University. The doctoral thesis shall be in a relevant area according to the specific position stated here. Since a position as postdoctor aims to give new holders of the doctorate the opportunity mainly to strengthen and develop their scholarly proficiency, we aim for those who have a doctoral degree not older than 3 years counting from last date of application.
The qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.
Assessment
We are looking for a scholar with well-documented merits in yeast (Saccharomyces cerevisiae) molecular biology, including genetics and strain constructions. The successful applicant should have experience in microscopy including single-cell analysis. Documented (peer-reviewed original papers) expertise in working with yeast peroxiredoxins and protein quality control/protein aggregation is considered advantageous.
Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.
Employment
The employment is limited, 2 years, and full time with placement at the Institute of Biomedicine. First day of employment as agreed.
For further information:
Please contact Professor Thomas Nyström, phone +46 31 786 2582, e-mail
thomas.nystrom@cmb.gu.seUnions
Union representatives at the University of Gothenburg:
http://www.gu.se/english/about_the_university/job-opportunities/union-representativesHow to apply
In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.
The application should contain:
• A cover letter giving a brief description of previous research experience, and a motivation to why you are applying
• A CV including a list of publications
• Proof of completed PhD
• Contact details of two references
Closing date: November 13, 2017
The University of Gothenburg promotes equal opportunities, equality and diversity.
Salary is determined on an individual basis.
Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.
Varaktighet, arbetstid
Heltid/ Ej specificerat
Publiceringsdatum2017-10-24ErsättningGöteborgs universitet tillämpar individuell lönesättning
Så ansöker duSista dag att ansöka är 2017-11-13
Klicka på denna länk för att göra din ansökanFöretagGöteborgs universitet
AdressGöteborgs universitet
Medicinaregatan 7B
40530 Göteborg
KontorsadressMedicinaregatan 7B
Jobbnummer 3763799
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