Researcher, Postdoctoral Fellow in Biomolecular NMR
Göteborgs universitet / Biologjobb / Göteborg
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Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.
• NMR is a rapidly developing biophysical tool to study biological phenomena at atomic level. Our group at the Department of Chemistry and Molecular Biology and the Swedish NMR Centre is the forefront of developing new NMR experiments, signal processing algorithms, automation of data analysis. The new methodology is immediately applied and tested in our studies of structure and dynamics of Intrinsically Disordered Proteins, large proteins systems, and in collaboration projects that we have with many groups in Sweden and worldwide.
• The Department of Chemistry and Molecular Biology and Swedish NMR Centre offers a dynamic international working environment with excellent infrastructure for studies in all areas of life science. Our facilities for structural biology include state-of-the-art 600-900 MHz Bruker NMR spectrometers, access to national super-computer infrastructure, as well as a fully equipped biochemistry laboratory for expression, purification, and biophysical characterization.
• More details on our research can be found at
http://www.nmr.gu.se. https://www.gu.se/english/about_the_university/staff/?languageId=100001&userId=xorevlJob assignments
Intrinsically Disordered Proteins (IDPs), whose mere existence was questioned not so long ago, constitute up to 30% of the human proteome, play key roles in most of the cell signalling processes, and are often implicated in many maladies including cancer, cardiovascular and neurodegenerative diseases. IDPs lack well defined structure, are often involved in promiscuous binding to multiple partners, defy the broadly accepted structure-function paradigm and, thus, pose new conceptual and methodological challenges for molecular structural biology. The researcher will be involved in developing an efficient NMR-cantered platform for studies of IDP and other challenging protein systems. In order to address inherent deficiencies of traditional NMR spectroscopy in resolution and sensitivity when dealing with IDPs, we will introduce new types of NMR experiments and design novel schemes of data collection and signal processing. The platform will be developed, tested, and fine-tuned in our study of key initial events of cell signalling in the B-cell receptor. We will elucidate, at the atomic level, the unknown mechanism that translates ligand binding at the immunoglobulin part of the receptor into phosphorylation of its intrinsically disordered cytosolic domains. The outcome of the project will have large impact in immunology and will be instrumental for rational drug design and finding new treatments for many of the important human diseases associated with IDPs.
Qualifications
To qualify as a researcher, the applicant must have completed a Swedish doctoral degree or must have a foreign degree corresponding to a Swedish doctoral degree.
The successful candidate should have a PhD in chemistry, physics or biology and a solid background in solution state biomolecular NMR spectroscopy; experience in Unix and programming (e.g. python, MATLAB, C). Experience in protein expression and purification as well as knowledge in other biophysical techniques and computational methods will be favourably considered.
The candidate should be highly motivated and able to work independently. Good English and communication skills are required.
Employment
Type of employment: Fixed-term employment, 16 months
Extent: 100 %
Location: Department of Chemistry and Molecular Biology, Gothenburg
First day of employment: 1 February 2019 or earliest possible date after
Appointment procedure
For more information and application:
https://www.gu.se/omuniversitetet/aktuellt/lediga-jobb Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser.
Varaktighet, arbetstid
16 månader Ej specificerat
Publiceringsdatum2018-12-13ErsättningGöteborgs universitet tillämpar individuell lönesättning
Så ansöker duSista dag att ansöka är 2019-01-03
Klicka på denna länk för att göra din ansökanFöretagGöteborgs universitet
AdressGöteborgs universitet
GU, Inst för kemi och molekylärbiologi
box 462
40530 Göteborg
KontorsadressLundbergslab, Medicinaregatan 9c
Jobbnummer 4509304
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