Preclinical And Translational Pk & Pkpd Scientist
AstraZeneca AB / Matematikerjobb / Göteborg
2020-12-15
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Visa alla matematikerjobb i Göteborg,
Mölndal,
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hela Sverige Visa alla jobb hos AstraZeneca AB i Göteborg,
Mölndal,
Södertälje,
Solna,
Stockholm eller i
hela Sverige Are you ready to join an inspirational team to be part of an exciting pipeline? Are you a specialist in PKPD modelling?
AstraZeneca is one of the world's most exciting biopharmaceutical companies. We're on a mission to turn ideas into life-changing medicines that improve patients' lives and benefit our society. We need highly who share our passion for science and have the drive and determination to meet the unmet needs of patients around the world!
Working at AstraZeneca means being entrepreneurial, thinking big, following the science and through teamwork make the impossible a reality. We are now recruiting a highly skilled and hardworking scientist with expertise in mathematical modelling, preferably applied in the field of pharmacokinetics-pharmacodynamics (PKPD), to join the Modelling & Simulation team within the Early R&I therapeutic area. The role is located at the dynamic site in Gothenburg, Sweden.
Respiratory & Immunology is one of the three main therapeutic research areas within AstraZeneca. Early R&I is a global function with research units in Gaithersburg, US, Cambridge, UK and Gothenburg, Sweden, and delivers candidate drugs into late-stage clinical development. The Modelling & Simulation team is part of the Drug, Metabolism and Pharmacokinetics (DMPK) department and based in AstraZeneca's world-class R&D center in Gothenburg Sweden. DMPK interacts with other functions in supporting Early R&I projects all along the value chain, from target selection all the way to market launch and Life cycle management.
What you'll do
With a true dedication for drug discovery you will support our portfolio within the R&I therapeutic area. You will deliver translational quantitative input for a broad range of drug modalities from target identification to life-cycle management. The position can be at Senior Scientist or Associate Principal Scientist level depending on the experience of the successful candidate.
Responsibility includes:
* Define and deliver the translational quantitative/PKPD strategy in projects from target identification to life-cycle management
* Identify the appropriate mathematical modelling approach (e.g. traditional PKPD modelling, non-linear mixed effects modelling, quantitative systems pharmacology) to deliver the aforementioned
* Design preclinical PKPD studies adequately so that effective conclusions can be made, contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
* In collaboration with key functions (e.g. bioscientists, translational and safety scientists, clinical pharmacologists and clinical Pharmacometricians) integrate the appropriate data to predict human pharmacokinetics and ultimately an efficacious dose
* Communicate scientific progresses both externally and internally
Essential for the role
The successful candidate have proven understanding of PKPD and hands-on modelling experience (e.g. empirical PKPD models and non-linear mixed effects models).
* PhD or equivalent experience in pharmacokinetics, pharmacology or related field, with focus on mathematical modelling of PKPD data, ideally in a preclinical/translational setting
* Specialist in PK and PKPD data analysis and associated interpretation and reporting. Furthermore, hands-on experience with modelling software (e.g. Phoenix, Matlab, Monolix, R, NONMEM, or similar)
* Excellent interpersonal skills, and ability to work in cross-functional teams as well as independently
* Scientific leadership evidenced by a publication track record and ability to independently own the drafting and review of publication manuscripts
* Ability to fluently communicate in English, both verbal and in writing
Desirable for the role
* Experience in pharmaceutical R&D
* Experience across several therapeutic modalities (e.g. small molecules, oligonucleotides, peptides, proteins, antibodies)
* Experience in statistical modelling
* Experience of practical experimental laboratory work.
So, what's next?
Are you already imagining yourself joining our team? Good, because we can't wait to hear from you!
For more information about the position please contact recruiting manager Rikard Pehrson at
rikard.pehrson@astrazeneca.comWelcome with your application no later than January 17, 2021
Where can I find out more?
Our Gothenburg site:
https://www.astrazeneca.com/our-science/gothenburg.htmlLife in Gothenburg:
https://www.movetogothenburg.com/Culture and atmosphere of the Gothenburg site:
https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2020-12-15ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2021-01-12
Klicka på denna länk för att göra din ansökanFöretagAstrazeneca AB
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-095319".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Jobbnummer 5489071
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