Physiologically-based pharmacokinetic modeller
AstraZeneca Mölndal / Apotekarjobb / Mölndal
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hela Sverige Physiologically-based pharmacokinetic modeller (RIA DMPK Modelling and Simulation
We are looking to further strengthen our capabilities in physiologically based pharmacokinetic (PBPK) modelling to support our development of inhaled and orally administered drugs for the treatment of respiratory, inflammatory and autoimmune diseases.
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
The Role
It is envisioned that you have a background in bio-pharmaceutics or environmental toxicology with experience of modeling topical drug exposure, i.e. through lung, nose, skin or eye. By using your experience you will be developing our understanding of how to design inhaled drugs and formulations to achieve an optimally targeted drug exposure in the lung. You will also be providing project teams with a general understanding of the relationships between molecular drug properties, pharmacokinetics (PK) and pharmacodynamic (PD) responses as well making quantitative predictions of drug efficacy and safety in human populations.
Major responsibilities:
Develop and apply PBPK models for inhalation in preclinical studies and for translation to man
Mathematically link estimated drug exposure in the lung to measured endpoints of drug efficacy in preclinical studies
Predict drug efficacy and safety in patient populations along with recommendations of appropriate route of drug delivery, dose and dosing interval
Work collaboratively with other functions as needed (e.g. bio-scientists and other modelling functions)
Prepare presentations related to the above for internal governance bodies
Lead external (academic) collaborations
Disseminate scientific achievements thorough conference attendance and preparation of research papers
Essential Requirements
PhD or equivalent level of experience of biopharmaceutical modelling & simulation of topical drug exposure such as via inhaled, nasal, dermal or ocular drug delivery
Strong mathematical skills and specialist user of some modelling and simulation software such as NONMEM, WinNonlin/Phoenix, Matlab
Strong skills in scientific writing and oral presentation
More information
For more information about the position please contact: Markus Fridén, Head of Modelling and Simulation (RIA DMPK), at +46 31 7065360.
Welcome with your application no later than October 18, 2015.
FOR FULL JOB DESCRIPTION AND TO APPLY, please visit
www.astrazeneca.se/karriarVaraktighet, arbetstid
Tillsvidare
Heltid
Publiceringsdatum2015-10-14ErsättningFast månads- vecko- eller timlön
Så ansöker duSista dag att ansöka är 2015-10-18
Ange följande referens när du ansöker: MOL000001W7
FöretagAstraZeneca Mölndal
AdressAstraZeneca Mölndal
43183 MÖLNDAL
KontorsadressPEPPAREDSLEDEN 1
MÖLNDAL
Övriga kontaktuppgifterTelefonnummer: 031-7761000
Jobbnummer 2479380
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