Research scientist, Early Respiratory & Immunology
AstraZeneca AB / Kemiingenjörsjobb / Göteborg
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hela Sverige Are you an enthusiastic lab-based scientist looking for a position where your technical expertise can make a difference to patients through experimental evaluation of potential new drug targets? Are you familiar with respiratory biology? Come and join the team that passionately follows the science and puts the patients first!
We have an exciting opportunity for an engaged and passionate scientist to play an important part as a Research Scientist in our Target Science team within Early Respiratory and Immunology (R&I). The position will be placed at AstraZeneca in Gothenburg, Sweden. In Target Science we focus on the identification and validation of novel targets and mechanisms addressing key biological disease drivers to enable a precision medicine approach to treating respiratory diseases. We are committed to selecting the right targets for the right patients.
In this role you'll be part of our broader Translational Science and Experimental Medicine (TSEM) organisation. Within TSEM, we are working in an open environment with a strong science focus and our work bridges basic science with clinical development. Our mission is to understand disease mechanisms at the molecular level closing the gap between bench science and bedside clinical practice.
What you will do
You will join a team of dedicated Target Scientists and have a key role in successfully validating therapeutic target ideas enabling important milestone investment decisions (Target Selection Investment Decision (TSID)).
In the everyday work you will:
• Experimentally evaluate new candidate targets resulting from unbiased approaches to target identification including genomics, phenotypic screening, and the application of artificial intelligence and machine learning.
• Validate potential new drug targets by generating high quality experimental data.
• Use and develop disease-relevant experimental model systems to enable experimental validation of new targets.
• Analyse your data and present your conclusions to the team.
Essential in the role
To take on this role, you need to have good networking and communication skills, with the ability to work efficiently in a team environment where you and your team support each other to deliver.
You should also have:
• A PhD in biology, cell biology or a related discipline, or significant scientific research training and lab-based experience.
• Strong experimental drive and background in basic science related to respiratory research is mandatory. Basic understanding of respiratory disease biology, including cell types, molecular pathways, and mechanisms (COPD, IPF; Cough, Bronchiectasis, especially).
• Basic knowledge and technical skills in cell biology, such as mammalian cell culture, primary cell line culture (fibroblast, epithelial cells, smooth muscle cells), transfections, siRNA, ASOs, qPCR, Western and automated Blots, IHC, IF. Experience with CRISPR is a plus.
• Experience with more complex culture models such as organoids and PCLS is a plus.
• Experience with, and good understanding of omics/genetic analysis/Bioinformatics is a plus.
• Industry experience and a good understanding of the drug development process is an advantage.
• Broad understanding of and the ability to apply state-of-the-art target validation technologies and methodologies along with excellent laboratory skills and the ability to experimentally address key scientific questions.
This is a laboratory-based role, requiring technical expertise and strong organisational skills. Your data will enable effective decision-making and ensure timely prosecution of pre-TSID projects. In this highly collaborative role, you need to have proven track record of scientific and experimental excellence and robust delivery of results.
Why AstraZeneca?
At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.
Why AstraZeneca in Gothenburg?
Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. Here, you'll feel a global atmosphere in a multinational environment. Collaboration comes in all forms - across teams, functions, countries and even companies.
With more than 2,900 employees from over 70 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.
What's next?
If this sounds like an interesting career opportunity - apply today! We look forward to getting to know you better and welcome your application, latest August 11, 2023. For further details around this position, you are welcome to contact the recruiting managers Roxane Paulin (roxane.paulin(at)astrazeneca.com) and Henric Olsson (henric.k.olsson(at)astrazeneca.com)
Note: Due to Swedish summer vacation period, the screening process may take a bit longer than usual. Please bear with us and we will get back to you as soon as possible when we are back in August.
Where can I find out more?
Global Gothenburg:
https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html Our Gothenburg site:
https://www.astrazeneca.com/our-science/gothenburg.html Life in Gothenburg:
https://www.movetogothenburg.com/ Ersättning Not Specified
Så ansöker du Sista dag att ansöka är 2023-08-01
Klicka på denna länk för att göra din ansökan Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-173120".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Kontakt AstraZeneca
karolina.zingmark@astrazeneca.com Jobbnummer 7938940
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