Thesis work: Tissue clearing and immunolabeling for 3D imaging
Randstad AB / Kemiingenjörsjobb / Mölndal
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Tssue clearing and immunolabeling of kidney, heart , and liver to enable 3D organ imaging
Thesis type: 30 credits
Project start: January 2023
Student location: On Site, Gothenburg Sweden
Do you have experience of and interest in working with histology? Would you like to develop tissue clearing protocols for whole organ imaging ? Then this Master thesis project at AstraZeneca might be of interest to you!
You will join Cell and Molecular Pharmacology (CMP) team that delivers key data within histology, imaging, biomarker, FACS and bioassay automation to Cardiovascular, Renal and Metabolism (CVRM) disease areas. Within the histology group we are at the scientific forefront of latest histology technique and image analyses.
Responsibilities
State- of- Art tissue clearing combined with fluorescent labelling (tissue structures/compounds/antibodies/proteins/cells) and imaging can provide valuable visualization of 3D structure together with target distribution through whole organ.
3D organ imaging is hampered due to low light penetration through the tissue. Major cause of low tissue transparency is light scattering caused by organ components such as lipids, pigments and collagen fibers. By using optical clearing agents (OCAs) these disturbing components are removed from the tissue, leading to improvement of light penetration and increasing tissue transparency and enabling whole organ imaging.
The goal of thesis is to optimize clearing protocol to achieve tissue transparency and multiplex fluorescent labelling in diverse mouse organs to enable 3D imaging
As master student you will be a part of our histology team and learn about tissue fixation, processing, labelling, and imaging.
We look forward working with you!
Qualifications
Essential Requirements
Well-organized and focused mindset
Strong oral and written communication skills.
Desirable Requirements
Desire to learn and try new things.
Application
Deadline 2022-11-04
About the company
At AstraZeneca, all of our employees make a difference to patients' lives every day. We operate in more than 100 countries around the world and are one of Sweden's most important export companies. With more than 2,400 employees from 50 countries, the vibrant Gothenburg site helps to support the entire life-cycle of AstraZeneca medicines, from drug discovery and clinical trials, to global commercialisation and product maintenance. Gothenburg is one of AstraZeneca's three strategic, global R&D centres, alongside Cambridge and Gaithersburg, and plays a central role in our mission to deliver life-changing medicines to patients.
Varaktighet, arbetstid
Full time Contract
Publiceringsdatum2022-10-20ErsättningNot specified
Så ansöker duSista dag att ansöka är 2022-11-04
Klicka på denna länk för att göra din ansökanFöretagRandstad AB
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "201412506".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Randstad AB (org.nr 556242-1718)
Arbetsplats Randstad
Kontakt Malin Fridholm
malin.fridholm@randstad.se Jobbnummer 7094540
Observera att sista ansökningsdag har passerat.