Postdoctoral Fellow
AstraZeneca Mölndal / Biologjobb / Mölndal
Observera att sista ansökningsdag har passerat.
Visa alla biologjobb i Mölndal,
Göteborg,
Partille,
Härryda,
Kungsbacka eller i
hela Sverige Visa alla jobb hos AstraZeneca Mölndal i Mölndal,
Södertälje eller i
hela Sverige AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
Project Title: Structure determination of ligands bound to a paramagnetically tagged target protein
Post Doc Location: AstraZeneca Mölndal, Sweden
Starting Date: January 2014 (24 months)
Main Supervisors:
AstraZeneca: Tomas Åkerud, Ph.D., Associate Principle Scientist, Structure and Biophysics, Discovery Sciences, Sweden
Leiden University: Marcellus Ubbink, Professor, Institute of Chemistry, Section Protein Chemistry, The Netherlands
University of Florence: Claudio Luchinat, Professor, CERM Magnetic Resonance Center, Italy
Description of Opportunity:
We have an exciting opportunity for a Ph.D. scientist to develop methodology to determine the orientation of ligands bound to proteins of pharmaceutical interest. The aim of the work is to produce information that is complementary to conventional methods for structure determination of protein-ligand complexes. This should enable more efficient synthetic chemistry efforts in a drug discovery programme. The work is multi-disciplinary in nature and includes secondments to Leiden University and the University of Florence, research centres with extensive experience in paramagnetic protein NMR.
This position is part of the FP7 - PEOPLE Marie Curie Initial Training Network "pNMR" (Pushing the Envelope of Nuclear Magnetic Resonance Spectroscopy for Paramagnetic Systems. A Combined Experimental and Theoretical Approach). For more information please visit
http://www.pnmr.eu/ (the "Jobs"-tab).
The role's main objectives
To enable more efficient synthetic chemistry efforts in drug discovery by determining the relative orientation of small molecule ligands to at least one drug target protein
To show that this can be achieved within a time-frame that is compatible with the time-lines in a drug-discovery programme
The role?s major responsibilities
Show strong initiative in conducting research, and bringing it to functional use within AstraZeneca and the drug discovery community
Interface with scientists from across many disciplines while at the same time being able to work independently
Strong written and oral communication skills
Ability to work effectively with colleagues and initiate collaboration
Tasks and methodology
Production of drug target protein with lanthanide binding tags rigidly attached
Determination of pseudo-contact shift (PCS) tensors for the lanthanide tagged proteins
Detection of transferred PCSs for several ligands
Structure calculations based on PCSs. Comparison with known crystal structures to assess quality of PCS-based structures
Minimum experience
A PhD in biomolecular NMR or closely related field
Preferred experience/requirements
Protein NMR assignments
Protein-ligand interactions and binding kinetics
Protein production
Paramagnetic NMR
Synthetic chemistry
More information
For more information about the position please contact Tomas Åkerud at +46 31 7064412
Publiceringsdatum2013-03-14Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2013-04-30
Ange följande referens när du ansöker: MOL000000YN
Ansökan kan tyvärr inte göras via e-post.
FöretagAstraZeneca Mölndal
AdressAstraZeneca Mölndal
43183 MÖLNDAL
KontorsadressPEPPAREDSLEDEN 1
MÖLNDAL
Övriga kontaktuppgifterTelefonnummer: 031-7761000
Jobbnummer 1494406
Observera att sista ansökningsdag har passerat.