Senior Research Scientist - Cellular Reagents
AstraZeneca Göteborg / Apotekarjobb / Mölndal
2016-08-30
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hela Sverige The role
To provide strong expertise in the competency of Cellular Reagent Generation and with a focus on cell line generation using traditional and precise genome editing approaches for use in cellular assays, target identification and target validation. To devise, champion and develop scientific areas aligned with project needs. To be an authority in the arena of cell science and precise genome editing, to lead this from a lab-based perspective and make significant contributions to the practical delivery of project goals. To coach and support more junior scientists by advising and challenging them and by providing expert advice to aid interpretation of complex data. To provide disciplinary scientific leadership and represent the department at internal interdisciplinary meetings in addition to external meetings and to publish novel science in high impact journals. To propose experimental strategies, troubleshoot problems and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.
It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem solving attitude. Good organisational skills are required and you should be comfortable in presenting your results. Excellent English is required, both spoken and in writing.
Tasks:
To develop cellular reagents for target based approaches and phenotypic assays, target identification, target validation
To design CRISPR-based strategies and tools required to generate cellular reagents to meet project needs
To perform confirmation of cellular/genetic manipulation and functional validation of engineered cells
To perform target identification and target validation studies in early projects
The following skills are highly desirable:
Development of stable cell lines utilising traditional, viral and Precise Genome Editing (CRISPR) techniques
Transient and stable transfection utilising different technologies such as electroporation (Maxcyte, Nucleofector, Amaxa), lipid and PEI
Knowledge of viral tools for expression and cell line generation
Isolation of clonal cell lines (MACS, FACS, limiting dilution)
Expert knowledge in the design and generation of Precise Genome Editing (CRISPR) strategies, tools and reagents required for cell line generation, target identification and target validation
Genetic (ddPCR, NGS, AmpliconSeq) characterization of engineered cell lines
Functional (phenotypic assays, expression analysis) characterization of engineered cell lines
Culturing and functional characterization of recombinant cell lines, primary cells and iPSC in both small (multi-well plates) and large (cell factories) scale
Experience of drug discovery and cell deliverables in an industrial or biotech setting
Practical knowledge of cell-based assays for drug discovery would be beneficial
Accountabilities.....
To read FULL JOBDESCRIPTION and to APPLY, please visit
www.astrazeneca.seVaraktighet, arbetstid
Visstidsanställning 6 månader eller längre
Heltid
Publiceringsdatum2016-08-30ErsättningFast månads- vecko- eller timlön
Så ansöker duSista dag att ansöka är 2016-09-19
Ange följande referens när du ansöker: GOT0000008J
FöretagAstraZeneca Göteborg
AdressAstraZeneca Göteborg
43183 MÖLNDAL
KontorsadressPEPPAREDSLEDEN 1
MÖLNDAL
Övriga kontaktuppgifterTelefonnummer: 031-7761000
Jobbnummer 3019625
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