Scientific Lead, Chronic Kidney Disease Late Stage Portfolio
AstraZeneca / Läkarjobb / Göteborg
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hela Sverige Do you have strong expertise and reputation in the kidney disease area? Are you excited by a role where you will provide key scientific leadership in your area of expertise by bridging early and late stage drug development? Would you like to apply your expertise in a company that are following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!
AstraZeneca is now looking to recruit a Director in Translational Science to the role as Scientific Lead for Chronic Kidney Disease Late Stage Portfolio within the Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden
CVRM Innovative Medicines (IMED) within AstraZeneca is accountable for the discovery and the development (up to phase II) of new drugs in the CVRM arena within three main strategic areas - cardiovascular/heart failure, metabolism (diabetes and NASH) and chronic kidney diseases. The continous scientific exchange between Early and Late Portfolio is one of the main requisites for building and sustaing our research pipeline. Translational Sciences (TS) Department in IMED CVRM has the remit to bridge early and late drug development by providing early target validation in human and by driving precision medicine approaches through biomarker science.
As a Scientific Lead for Chronic Kidney Disease Late Stage Portfolio you will have a key role in supporting our late phase projects, mainly Roxadustat and Lokelma, to ensure efficient bridging of any aspect related to target biology, drug MoA and biomarkers for patient selection, including transfer of learnings and opportunities from the late stage portfolio into the early research. In this role, you are also expected to lead the Translational Science strategy in CKD across the pipeline, encompassing human target validation, biomarkers and precision medicine. This is a senior individual contributor position based in Gothenburg, Sweden.
Main Duties and Responsibilities
* Single-point accountability for bridging early and late development for Roxadustat and Lokelma, and generally for late stage programs and initiatives around kidney diseases
* Core member of the Life Cycle team and responsible for interaction with key stakeholders from late stage organization. Accountable for providing early research/TS input into late development projects at all levels, from clinical study design, through regulatory questions/filings to publication and communication strategy
* Core member of TS leadership team and responsible for interaction with key stakeholders within CVRM for set-up and execution of project strategy. Accountable for identifying and driving key internal and external opportunities, activities and collaborations to strengthen the science around the late stage portfolio projects
* Accountable for leveraging opportunities arising from late stage portfolio to support and expand early portfolio
* Accountable for sustaining and expanding the external network around own area of expertise and for bringing back key inputs to the team
* Providing key expert input in the development of communication material concerning the MoA of our compounds, in close collaboration with the Medical Affairs function
* When appropritate, accountable for leading investigational subteams aimed to fully understand the clinical profile of the late-stage assets
* Drive high impact publications of relevance to the project
* As key CKD expert in TS, responsible for Translational Sciences strategy in CKD at the portfolio level, including key external collaborations and opportunities for accessing high-quality human genomic and omics dataset. Responsible for leading a TS subteam of representatives in the various CKD projects to ensure TS plans harmonization and delivery
* Expected to support and grow CKD science and expertise at the CVRM level, by contributing to CKD overarching strategy and portfolio
Essential Requirements
* MD, PhD in related field
* At least 10 years experience in Pharma industry, with clear understanding of the drug development process and regulatory requirements and with a track record of academic merits and current academic affiliation
* Strong expertise in the kidney area, preferably with specific focus on biological aspects of hypoxia-inducible factor- and electrolytes balance related mechanisms
* Proven experience in Translational Sciences area in CKD (biomarkers, human target validation and precision medicine) as demonstrated by a outstanding publications record, track record of collaborations and a strong external network
* Excellent communication and collaboration skills, strategic leadership and proven ability to influence and develop people and organisations.
If you are interested, apply now!
For more information about the position please contact Maria Chiara Magnone, Head of Translational Science; .
Welcome with your application no later than May 1st, 2018.
AstraZeneca is a global, innovation-driven biopharmaceutical company that provide an unique environment where employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity. AstraZeneca is an equal opportunity employer.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2018-04-11ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2018-05-02
Ange följande referens när du ansöker: R-025765
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
ulrica.marklund1@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparedsleden 1
Jobbnummer 4077420
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