Postdoctoral position
Sveriges lantbruksuniversitet / Biologjobb / Uppsala
2010-03-11
Observera att sista ansökningsdag har passerat.
➡️ Klicka här för den senare publicerade platsannonsen "Postdoctoral position" (publicerad 2023-12-20) ⬅️
Visa alla biologjobb i Uppsala,
Östhammar,
Sigtuna,
Österåker,
Håbo eller i
hela Sverige Visa alla jobb hos Sveriges lantbruksuniversitet i Uppsala,
Östhammar,
Solna,
Stockholm,
Ekerö eller i
hela Sverige Swedish University of Agricultural Sciences
Department of Anatomy, physiology and Biochemistry
Postdoctoral position
• Development of spider silk scaffolds for growth of functional islets of Langerhans
The Faculty of Veterinary Medicine and Animal Science is one of four faculties at SLU with 500 employees and 1000 bachelor, master and doctorate students. The Faculty office and most of the departments are located in Uppsala, but important research and teaching activities are also carried out in Skara.
The faculty is the only faculty in Sweden with a specific responsibility for teaching and research in veterinary medicine and animal science. The research and education aim to promote the health and well-being of animals as well as humans and to develop a biologically and economically sustainable animal management.
Background
Diabetes mellitus (DM) refers to a group of chronic metabolic disorders that are among the most prevalent, costly and debilitating diseases in the world. DM is to a large extent due to defects in the endocrine pancreas, the islets of Langerhans. These islets have so far been difficult to propagate and maintain in vitro. The establishment of an environment optimized for islets of Langerhans is necessary both for the study, propagation and maintenance of beta-cells, and for the design of an artificial, islet-carrier for transplantation. In order to do so, a highly versatile biomaterial is needed.
Aims
This project aims at taking advantage of a newly generated synthetic variant of the toughest fiber known – the spider silk – for the establishment of scaffolds that allows studies of pancreatic islets and insulin-producing cells. This will enable detailed functional and molecular studies as well as provide the basis for an islet-carrier suitable for transplantation.
Methods
Signal-transduction in the individual islets and islet cells will be studied under different growth, function and survival promoting conditions, and for different periods of time, in various scaffolds. Islet cell growth, function and survival will be monitored with the help of various fluorescent dyes and biosensors for specific steps in the signal-transduction pathway. In this way we will define conditions that are optimal for islet cell growth, function and survival. Furthermore, underlying molecular mechanisms will be studied whereby key signal-transduction pathways in the individual islet cells can be assessed.
Criteria of the applicant
The prerequisite for this position is a PhD degree in the subject area. The PhD degree should have been awarded no longer than three years before the final application date, unless there are mitigating circumstances. Prior experience of islet isolation (human and mice), cell culture and imaging on scaffolds is desirable.
Most of the work will be carried out at The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institute, Solna, Stockholm
Duration: 2 years Start: May 2010
SLU is an equal opportunity employer.
Further information:
My Hedhammar
018-471 41 91
my.hedhammar@afb.slu.seAcademic union representatives:
Jennifer Strandman, SACO
• 46 (0)18-67 26 34
Monica Östman (ST)
• 46 (0)18-67 15 36
Peter Syrjänen, SEKO
• 46 (0)18- 67 10 57
We welcome your application marked with ref no 780/10.
The application should be written in English.
Please submit your application to the Registrar of SLU, P.O. Box 7070, S-750 07 Uppsala, Sweden or
registrator@slu.se no later than March 26, 2010.
www.slu.seFor a complete advt: personal.slu.se/job
Publiceringsdatum2010-03-11Arbetstider och omfattningVisstidsanställning 6 månader eller längre
Heltid
Full-time. For a period of two years. Start: May 2010
ErsättningFast lön
Så ansöker duAnge följande referens när du ansöker: 780/10
Ansökan kan skickas till e-postadress:
Registrator@slu.seFöretagSveriges lantbruksuniversitet
AdressSveriges lantbruksuniversitet
Box 7070
75007 UPPSALA
KontaktuppgifterTelefonnummer: 018-671000
Jobbnummer 604687
Observera att sista ansökningsdag har passerat.