Post Doctoral Opportunity - Exosomes
AstraZeneca Göteborg / Biologjobb / Mölndal
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Description
This is a unique opportunity to be part of a global, interdisciplinary team of highly skilled and motivated post doctoral scientists, dedicated to investigating the therapeutic potential of engineered exosomes as tissue-specific delivery vehicles for gene manipulation. Recent studies have demonstrated that exosomes can be used as a delivery system for therapeutic agents such as siRNA and small molecules directly to specific diseased tissues to elicit favourable biological responses in vitro and in vivo. These post doc positions seeks to build on these reports by using cutting-edge cell and protein engineering methodologies to develop novel platforms to enable:
1) RNA-loading into exosomes; in-cell loading of RNA cargo into exosomes using designed RNA binding proteins (Gothenburg, Sweden).
2) Targeting of exosomes to diseased tissue; develop technologies for enhanced targeting of exosomes to disease tissue through the display of targeting ligands at the surface of exosomes by cell-line engineering and/or combined with bio-orthogonal chemistry for introduction of complex non-peptide ligands at the surface of the exosome (Gothenburg, Sweden).
3) Protein-loading and affinity purification of exosomes; controllable in vitro loading of protein and RNA molecules into exosomes, and 2) exosomal surface marker modification to facilitate selective purification of loaded exosomes (Alderley Park, UK).
In addition, the applicant will form part of a large team of cell and protein scientists within a vibrant and fast-paced industrial drug discovery setting, focused on delivering valuable new medicines to the patients that need them.
As a Postdoctoral Scientist in Exosomes it is essential that you have:
A PhD in Biological Sciences, with a strong cell biology or biochemical focus
Experience of isolating, characterising and manipulating exosomes
Expertise with standard molecular biology techniques, gene manipulation, protein engineering and mammalian cell culture
Excellent influencing and problem solving skills, as well as the confidence to work with ambiguous results
A proven record of publication in reputable, peer-reviewed journals .........
To READ FULL JOBDESCRIPTION and TO APPLY:
http://gs.globalsuccessor.com/fe/tpl_astrazenecav2.asp?newms=jj&id=64470&----JOB-PREVIEW-MODE----Varaktighet, arbetstid
Visstidsanställning 6 månader eller längre
Heltid
Publiceringsdatum2016-03-18ErsättningFast månads- vecko- eller timlön
Så ansöker duSista dag att ansöka är 2016-04-18
Ange följande referens när du ansöker: POSTDOC114
FöretagAstraZeneca Göteborg
AdressAstraZeneca Göteborg
43183 MÖLNDAL
KontorsadressPEPPAREDSLEDEN 1
MÖLNDAL
Övriga kontaktuppgifterTelefonnummer: 031-7761000
Jobbnummer 2733389
Observera att sista ansökningsdag har passerat.