Expert in Biomarkers Discovery and Development
AstraZeneca AB / Biomedicinjobb / Göteborg
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hela Sverige Do you have expertise in Lipid and Metabolomic Biomarker Discovery and Development in Cardiovascular, Renal and Metabolic (CVRM) diseases? Would you like to apply your expertise at a company that are accelerating the science and turn ideas into life changing medicines? Join us to be part of the discovery of future life changing medicines in the CVRM disease area!
We are now recruiting an Expert in Biomarkers Discovery and Development to join the Biomarker team within Translational Science and Experimental Medicine (TS&EM) function in Early CVRM therapeutic area. The position is placed at AstraZeneca's dynamic R&D site in Gothenburg, Sweden. This is a senior role and the career level will be aligned to your experience and qualifications for the role (Associate Principal Scientist or Associate Director).
Early CVRM is one of three main therapeutic research areas within AstraZeneca that deliver candidate drugs into late-stage clinical development. CVRM TS&EM has the remit to bridge pre-clinical, early and late drug development by providing early target validation in humans and by driving precision medicine approaches through biomarker discovery and development based on understanding of human diseases and access to human patient samples. The biomarker team within TS&EM is accountable for pre-clinical to clinical biomarker delivery which includes: (i) biomarker discovery for identification of target engagement and proof-of-mechanism biomarkers (ii) generation of target related precision medicine hypothesis (iii) analysis of explorative biomarkers in clinical projects and (iv) outsourcing decision-making biomarkers in clinical studies.
Main duties and responsibilities
As an Associate Principal / Principal Scientist in the Biomarker team, you will play a key role in the biomarker delivery and contribute to building the biomarker strategy to progress clinical projects and novel science. Your focus will be to identify and develop lipid and metabolite biomarkers to the Early CVRM portfolio. You will have the opportunity to try novel ideas and technologies, make judgements about complex scientific information, develop innovative solutions and applying comprehensive cross-functional understanding. You will also be responsible for outsourcing decision-making biomarkers according to Good clinical practise (GCP) as well as explorative biomarkers in the clinical projects, a process that involves CRO selection, Due Diligence process, contracts, assay validation, and sample monitoring.
Collaboration is critical for successful delivery of drug projects. At AstraZeneca we work together across boundaries to make the impossible a reality. You will thus work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators.
Essential Requirements
* Ph.D in a relevant scientific discipline and 10 years post-doctoral or industrial experience.
* Deep expertise in lipid and metabolite biomarker discovery and development in cardiovascular, renal and metabolism
* Expert knowledge in a range of analytical techniques for biomarker analysis (lipids, small molecules)
* Knowledge in biology of cardiovascular and metabolic diseases
* Experience of leading biomarker efforts aligned to drug discovery
* Ability to plan and report all work to appropriate standards for outsourcing clinical biomarkers
* Problem solving studies by identification of issues and where necessary designing experiments to overcome problems.
* Ability to maintain awareness of relevant areas of research, drug discover/development technologies and regulatory requirements through reading scientific literature and guidelines
* Passion for delivering and promoting excellence in science
* An excellent publication track record in the field
* Good project management and matrix leadership skills.
* Ability to collaborate and communicate well cross functions.
* Excellent English, both verbal and written
Desirable Requirements
* Experience in outsourcing of biomarkers according to GCP in clinical studies including CRO selection, Due Diligence process, contracts, assay validation, and sample monitoring.
* Experience of biostatistics, multivariate data analysis, and statistical learning
We would like to know more about you. If you are interested to know more about us, apply now!
For more information about the position please contact hiring manager: Pia Davidsson at
Welcome with your application no later than January 20th, 2020
Additional information
Our Gothenburg site:
https://www.astrazeneca.com/our-science/gothenburg.htmlLife in Gothenburg:
https://www.movetogothenburg.com/Culture and atmosphere of the site:
https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2019-12-20ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2020-01-17
Klicka på denna länk för att göra din ansökanFöretagAstrazeneca AB
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-069061".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Jobbnummer 5014921
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