Postdoctoral Fellow in Acute myeloid leukemia - treatment respon
Göteborgs universitet / Biologjobb / Göteborg
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Group Linda Fogelstrand at the Department of Laboratory Medicine is recruiting a postdoctoral fellow for a project on acute myeloid leukemia.
Subject area
Acute myeloid leukemia - treatment response
Subject area description
Acute myeloid leukemia (AML) is the most common form of acute leukemia. Unfortunately, the prognosis is poor, mostly due to high frequency of relapses using the current treatment strategies. Over the last years, it has become increasingly evident that the response to AML treatment, assessed as measurable residual disease (MRD), is a very strong prognostic factor. MRD analyses are also of interest for early detection of relapse. However, problems with standardization and applicability in individual patients hamper clinical usage of MRD analyses. The overall aim of the research in the group is to improve the basis for treatment decisions for children and adults with AML. We do this primarily through improvement and evaluation of MRD analyses. We also work on understanding the role of other factors, such as the surrounding bone marrow composition, for the success of treatment. The research group is located at the Department of Laboratory Medicine, Institute of Biomedicine and is closely linked to the hematology diagnostics units at Sahlgrenska University Hospital.
The success of AML treatment is largely dependent on the presence/absence of residual leukemic cells. What is less known is how the bone marrow environment during treatment affects the treatment efficiency and outcome. Since AML is a very heterogeneous disease, the role of the microenvironment might differ depending on the treatment, host and leukemia genetics. In the current project, we will evaluate the importance of residual leukemic cells and the surrounding healthy bone marrow during treatment of AML. We will use conventional techniques such as flow cytometry and RT-qPCR, our newly developed MRD analysis using next generation sequencing, and single cell applications.
Job assignments
The postdoctoral project will include analysis-based work on already obtained flow cytometry and sequencing data and some experimental work. In the group, we collaborate closely with clinical hematologists, pediatric oncologists and experimental research groups nationally and internationally. Due to the collaborative nature of the project, it might include stays at other labs.
Eligibility
An achieved doctoral degree is compulsory for a position as postdoctor at Göteborg University. The doctoral thesis shall be in a relevant area according to the specific position stated here. Since a position as postdoctor aims to give new holders of the doctorate the opportunity mainly to strengthen and develop their scholarly proficiency, we aim for those who have a doctoral degree not older than 3 years counting from last date of application.
The qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance.
Assessment
PhD in a relevant field. The postdoctoral fellow is well acquainted with flow cytometry of leukocytes and preferably has experience from hematopoiesis or leukemia research, single cell techniques, RNA sequencing and bioinformatics. In addition to previous experience from the above-mentioned areas, the post-doctoral fellow is highly motivated, used to work independently and has good interpersonal and problem-solving skills.
Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance
Employment
The employment is full time and temporary, two years, with placement at the Institute of Biomedicine. First day of employment as agreed.
Appointment procedure
Suitable candidates will be interviewed, preferably in person. Personal skills and previous experience will be evaluated and references will be contacted.
For further information:
Please contact
Linda Fogelstrand, MD, PhD, Associate Professor
Phone: +46 766 314 811
Email:
Linda.Fogelstrand@clinchem.gu.seWebpage:
https://biomedicine.gu.se/ominst/avd/labmed/forskare/linda-fogelstrandUnions
Union representatives at the University of Gothenburg:
http://www.gu.se/english/about_the_university/job-opportunities/union-representativesHow to apply
In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline. The selection of candidates is made on the basis of the qualifications registered in the application.
The application should contain:
• A cover letter giving a brief description of previous research experience, and a motivation to why you are applying
• A CV including a list of publications
• Proof of completed PhD
• Contact details of two references
The University of Gothenburg promotes equal opportunities, equality and diversity.
Salary is determined on an individual basis.
Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.
Varaktighet, arbetstid
The position is temporary, two years. Full time
Publiceringsdatum2019-07-05ErsättningSalary is determined on an individual basis.
Salary is determined on an individual basis.
Så ansöker duSista dag att ansöka är 2019-08-15
Klicka på denna länk för att göra din ansökanFöretagGöteborgs universitet
AdressGöteborgs universitet
Box 440
40530 Gothenburg, Sweden
KontorsadressMedicinaregatan 9A
Jobbnummer 4841819
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