Senior Scientist with LC/MS experience requested to AstraZeneca
Adecco Sweden AB / Läkarjobb / Mölndal
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hela Sverige We are now looking for a Senior Scientist with LC/MS experience, for a consultant assignment sited at our customer AstraZeneca in Mölndal. Overall, the role involves performing high quality bioanalysis and developing analytical methods using LS/MS technique. The assignment is to start immediately and proceed initially for 12 months.
AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity. We are building a new bioanalysis capability to support our nucleotide projects and we already have quite an active portfolio which requires immediate support hence the need for some contractors.
The arena
Innovative Medicines, Drug Safety and Metabolism, Translational Safety, Pre-clinical Bioanalysis & Toxicokinetics (BA/TK).
The pre-clinical bioanalysis and TK group are responsible for the analysis of small molecule drug substances in biological samples generated in support of investigational toxicology studies and Pre FTIM Rodent GLP studies.
This new role will expand the remit of the team beyond small molecules by including nucleotide bioanalysis for toxicology and PK, PK/PD studies and encoded proteins for our modified mRNA projects.
The role
The successful candidate will be responsible for performing high quality bioanalysis within the new DSM capability for analysis of nucleotide therapeutics and associated encoded proteins. This will involve developing analytical methods using LC/MS-MS techniques as well as pre-fractionation approaches (homogenization, extraction, solid-phase extraction, affinity chromatography, antibody capture etc), implementation of the methods and supporting non-clinical studies.
The senior scientist is responsible for delivering quality in vivo PK data to support the nucleotide project portfolio. He/she develops methodology for quantification of oligonucleotide as well as encoded protein in plasma or other matrices using state of the art analytical techniques and reports methodology, data and PK evaluation to the customer.
The role requires interactive, effective communication providing clear data and interpretation to projects and contribution to the DMPK scientific strategy. The role requires making judgments about complex scientific information sets, developing innovative solutions and applying comprehensive cross-functional understanding.
In this role you are responsible for managing your own workload and timely delivery of appropriate quality data
Qualifications
• The candidate should have an expertise in range to technical skills, specifically the use of LC/MS/MS techniques as well as homogenization, extraction methods, and antibody capture techniques to analyse for large molecules (nucleotides, proteins, peptides) and other automated processing and analysis equipment would be advantageous.
• Develop and set up bioanalytical methods for quantification of nucleotides (oligonucleotides, microRNA, modified mRNA) and endcoded proteins for the modified mRNA projects.
• Perform problem solving studies by identification of issues and where necessary designing experiments to overcome problems.
• Influence study directors to ensure appropriate samples are taken to define the exposure and kinetics of the candidate drug.
• Plan and report all work to appropriate standards (Good Laboratory Standard, GLS) and keep project teams apprised of findings.
• Significant experience in pharmacokinetics and reasonable understanding of PK/PD principle. Perform PK and TK calculations including interpretation of the data generated, in collaboration with colleagues in innovative medicines (e.g DMPK and Toxicology project leaders).
• Identify new approaches and technologies that would improve our ability to support projects.
• Assist in the identification and evaluation of contract research organisations and coordinate method transfer as required.
• Maintain awareness of relevant areas of research, drug discover/development technologies and regulatory requirements through reading scientific literature and guidelines.
We are looking for someone with excellent communication skills, both verbal and written.
What do we offer?
Adecco is the world's largest recruitment and staffing company and our most important asset is our qualified employees. With us, and on our customer assignments, you, as a consultant, will be appreciated for your difference-making competence! Your bank of experience will grow, as will your social and professional network of contacts. Adecco can offer you the opportunity of interesting assignments at attractive companies, of positions that perhaps never will be put on the open market.
We want you to feel good and will give you subsidies for preventive healthcare and discounts on training cards. In order for you to feel secure, you will also be covered by insurance and corporate healthcare.
Are you interested?
Then you should apply as soon as possible! The positions are to be filled immediately, and, for that reason, work with recruitment is being done on a continual basis. Attached CV should be written in English. Don't hesitate and apply now.
We strongly look forward to your application!
Publiceringsdatum2014-09-01Arbetstider och omfattningHeltid Visstid
ErsättningFast lön
Så ansöker duSista dag att ansöka är 2014-09-14
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Klicka på denna länk för att göra din ansökanKontaktJoana Lotffi
Joana.Lotffi@adecco.seFöretagAdecco Sweden AB
AdressAdecco Sweden AB
Götgatan 11
41105 GÖTEBORG
KontorsadressGötgatan 11
Övriga kontaktuppgifter Jobbnummer 1981651
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