Senior Scientist, Large Scale Synthetic Chemistry
AstraZeneca / Logistikjobb / Göteborg
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hela Sverige Are you an experienced organic chemist with expertise in large scale synthetic chemistry? Are you excited by challenging, creative chemistry and state of the art equipment for large scale synthesis? Would you like to apply your expertise in a company that are following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!
AstraZeneca is now looking to recruit a Senior Scientist focused on large scale synthetic chemistry to join the Early Chemical Development (ECD) function within Pharmaceutical Sciences at AstraZeneca. The position is placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.
Pharmaceutical Sciences is a department within our Innovative Medicines and Early Development (IMED) Biotech unit. The vision for Pharmaceutical Sciences is to deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes and manufacturing of Active Pharmaceutical Ingredients (API) across all the AstraZeneca therapy areas. Within Pharmaceutical Sciences, ECD is responsible for developing manufacturing routes and processes as well as delivering batches of drug substance for all projects in the late discovery and early development portfolio.
The Large Scale Synthetic Chemistry team in Gothenburg delivers high-quality API batches in the range of 100-1000 g through development of great chemistry, innovative routes and creative solutions. The laboratory is the single company wide asset for large scale, non-GMP manufacturing of API for pre-clinical toxicology studies for all therapy areas. The Large Scale Synthetic Chemistry team supports the projects with the highest priority, most technically challenging chemistry in the AstraZeneca early phase portfolio and has access to top-quality labs and equipment, including e.g. reactors up to 100L, flow- and high-pressure reactors, and a wide range of modern analytical instruments.
Main Duties and Responsibilities
As a member of the Large Scale Synthetic Chemistry team, you will work closely with both medicinal chemists in drug development projects and process chemists to explore and develop safe, efficient and cost-effective synthesis routes to produce drug candidates. Key deliverables are:
* With strong emphasis on SHE aspects, explore and develop experimental strategies, troubleshoot problems and synthesize organic molecules in the range of 100-1000 grams
* Plan, prioritise and perform own work and actively collaborate with the drug project synthesis teams.
* Demonstrate expertise in synthetic and analytical chemistry, purification and crystallisation
* Provide stringent documentation of experimental results in an electronic labjournal, as well as writing up campaign and development reports.
* Publish novel work in peer reviewed journals
Essential requirements
* Ph.D. degree or equivalent in Organic Chemistry with several years of post-graduate research experience, preferably from work with route development and large-scale synthesis of complex organic molecules.
* Strong theoretical and practical knowledge of organic chemistry, with good awareness of current developments in the literature
* Able to identify, develop and apply new technologies and ways of working within large scale synthetic organic chemistry.
* Ability to independently design, plan and execute multistep syntheses to be able to manufacture kilogram campaigns together with team members.
* Creativity in handling a wide range of synthetic challenges
* Ability to coach peers for enhanced individual and team performance and development
* Strong collaborative and communication skills with experience of interacting effectively and work collaboratively across interfaces of disciplines
* Curious and innovative mindset
If you are interested, apply now!
For more information please contact recruiting manager Hans Emtenäs on
Welcome with your application no later than January 20th, 2019.
Learn more about AstraZeneca Gothenburg:
https://www.astrazeneca.com/our-science/gothenburg.htmlAstraZeneca is a global, science-driven biopharmaceutical company. We turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. Here, we see the impact of our collective ideas and expertise, and the power of science to deliver them.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2018-12-17ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2019-01-14
Ange följande referens när du ansöker: R-039877
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
ulrica.marklund1@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparedsleden 1
Jobbnummer 4513884
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