Senior Scientist In Pk & Pkpd - Proffice Life Science AB - Apotekarjobb i Göteborg
Senior Scientist In Pk & Pkpd
Proffice Life Science AB / Apotekarjobb / Göteborg
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Preclinical and Translational PK & PKPD Scientist at AstraZeneca, Mölndal

We are now looking for a preclinical and translational PK & PKPD scientist to AstraZeneca in Mölndal. You will work as a consultant at Proffice Life Science and you will be placed in the CVMD iMed DMPK department, Section Head of Modelling and Simulation, AstraZeneca Mölndal. The assignment is for two years, until 2016-06-01 with a start as soon as possible.


This temporary role as a translational PK & PKPD scientist will help provide projects with understanding and integration of the correlation between in-vitro and in-vivo ADME properties and the relationship between pharmacokinetics (PK) /toxicokinetics (TK) and pharmacodynamic (PD) responses including biomarkers for mechanism of action.

Major responsibilities:

* Define and deliver the preclinical, translational PKPD strategy for efficacy and safety, in projects from Target Identification to Life Cycle Management
* Design preclinical and forward/backward translational PKPD and TKPD studies and report results and interpretations to project teams
* Deliver drug-drug interaction (DDI) predictions and risk assessments to project teams
* Contribute to estimation of safety margins and make recommendations and predictions on human efficacious dose and exposure
* Evaluate and interpret PKPD and TKPD data to prepare for internal governance bodies
* Work collaboratively with other functions as needed to deliver the above (e.g. bioscientists, translational scientists, safety scientists, clinical pharmacology and pharmacometricians)
* Document the work according to AstraZeneca GLS standards
* Contribute proactively to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared
Key Deliverables

* Deliver the PK, DDI, PKPD and TKPD elements to project teams within the agreed timelines and to the right quality

Business: Proffice Life Science

City: Göteborg

Deadline for applications: 2014-06-09, selection is done continuously

More information: contact Camilla Bågenholm, or 0733-434777.


* PhD or equivalent level of experience in quantitative PK and PD related modelling & simulation of biological systems, ideally in a preclinical/translational setting
* Track record of defining quantitative modelling strategies across several therapeutic modalities (e.g. small molecules, oligonucleotides, proteins, antibodies)
* Track record of ability to meet timelines to pre-specified quality and cost
* Specialist in modelling and simulation tools such as NONMEM, WinNonlin/Phoenix, Matlab, SimCyp
* Understanding of integrative aspects of DMPK and pharmacology/safety aspects of drug discovery and development
* Experience in pharmaceutical R&D
* Experience in operating cross-functionally

The successful candidate should have a strategic thinking and be a communicative team player that likes to work within a group and collaborate while meeting deadlines. As a person you should be organized, accurate and be able to work independently. Also, the perfect candidate should have a passion for customers as well as develop people and organisation. Personal qualities will be important in the selection process. Please specify your knowledge for this position and why you are the perfect candidate for this assignment.

Please apply on

Last application day is 2014-06-09. Since selection is done continuously we prefer receiving your application as soon as possible. For further information please contact Camilla Bågenholm, [ mailto: ] or 0733-434777.

Organization/Business description:
Proffice Life Science is the leading Nordic specialist of temporary recruitment services within the Biotech and Chemtech industries. We are able to provide our Nordic clients with highly skilled and experienced specialists from all over Europe.

All consultants, employed by Proffice, are specialists. Proffice is one of the largest and most well-renowned staffing agencies in Sweden. All consultants, hired by Proffice, have secure and permanent employment contracts with a certified staffing agency. We offer excellent benefits and personal development opportunities within a wide range of positions and industries.

Our clients expect only the best from Proffice and we expect only the best from our consultants. As you will spend your working day on our clients' premises, you will have to not only be an expert in your field, but also a flexible, independent and social member of the team. You thrive on new challenges and welcome new opportunities. If this appeals to you, we offer a stimulating job, with excellent benefits such as private medical insurance, discounted gym membership and further contributions to health care related activities.

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Så ansöker du
Sista dag att ansöka är 2014-06-09
Ange följande referens när du ansöker: 200585018
Klicka på denna länk för att göra din ansökan

Camilla Bågenholm

Proffice Life Science AB

Proffice Life Science AB
Östra Hamngatan 23
41110 Göteborg

Östra Hamngatan 23, 41110 GÖTEBORG


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