Senior Scientist Dmpk - Poolia Sverige AB - Kemistjobb i Göteborg
Senior Scientist Dmpk
Poolia Sverige AB / Kemistjobb / Göteborg
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AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a phenomenal workplace culture that encourages innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.


Om tjänsten
We are looking for a motivated individual to take on take on the role as Drug Metabolism and Pharmacokinetic (DMPK) Design Leader (DDL) for 12 months. Alternatively, it is an opportunity for a highly talented indivudal with less specific experience to assist an experienced DDL whilst training for the role. The DDL role is a strategic and scientific role where you will work closely with Medicinal Chemistry, Bioscience and representatives from other functions in drug discovery. You will influence chemical drug design by optimizing the ADMET (absorption, distribution, metabolism, excretion, toxicity) for compounds within projects. In addition to oral drugs, the task is also to optimize inhalation properties for projects aiming for this route of administration.
The successful applicant will contribute to RIA drug design teams by providing DMPK expertise and input to the design of new compounds. This includes analysis of ADMET and efficacy data and to develop a strategy for how to improve these and subsequently influence project progression.
You are expected to have understanding of DMPK and chemistry to be able to provide advice and interpretation of complex drug discovery data.

Dina arbetsuppgifter i huvudsak
* Lead DMPK-related activities and the optimisation of compounds by balancing the properties associated with absorption, distribution, clearance, elimination and lung targeting to ensure that DMPK challenges are thoroughly assessed and resolved
* Deliver DMPK input and data to projects within agreed timelines and to the right quality
* Accountable together with Medicinal Chemistry, Bioscience and Safety, for compound design and effective cross-discipline optimization and Design-Make-Test-Analysis (DMTA) cycles in drug discovery
* Apply an understanding of DMPK and physicochemical properties to support/influence compound design, project progression and project strategy
* Responsible for leading, coordinating and engaging with RIA DMPK colleagues in project related activities
* Prepare clear presentations related to the above for internal

Vem är du?
* Formal training or proven experience of working with pharmacokinetics and drug metabolism.
* PhD or equivalent experience in a relevant discipline (Medicinal, Organic or Physical Chemistry or bio-pharmaceutics/pharmacokinetics)
* Understanding of correlations between physicochemical characteristics and their influence on DMPK properties and subsequent design of new compounds.
* Experience from drug discovery cross-functional work and compound/project progression is desirable
* Ability to engage and collaborate across boundaries with a problem solving attitude and focus on delivery

This is a consulting assignment at AstraZeneca for 12 months starting 2020-02-01 or asap.

We look forward to receiving your application as soon as possible.

Varaktighet, arbetstid
Heltid Visstid, mer än 6 månader

Fast lön

Så ansöker du
Sista dag att ansöka är 2020-01-14
Klicka på denna länk för att göra din ansökan

Poolia Sverige AB


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