Senior Scientist - Physical Science
AstraZeneca AB / Biomedicinjobb / Göteborg
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hela Sverige At AstraZeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.
Inhalation Product Development (IPD) at AstraZeneca is a multinational organization that combines decades of experience in inhalation technology. Our vision is to develop and provide to patients best-in-class, innovative and sustainable products to deliver medicine via inhalation. To achieve innovation in inhalation formulation development, we depend upon advanced materials characterization of both our active and inactive ingredients.
We're looking for two talented and motivated Senior Scientists - Physical Science, to join our material science and solid-state characterization team within Inhalation Product Development (IPD) unit in Gothenburg. One of the roles will have a key focus on surface characterisation and ToF-SIMS analysis for inhalation projects.
Main duties and responsibilities
This is primarily a lab-based role with a high focus on physical characterisation of critical properties of the drug substance and excipients in the field of inhalation. Your role will be key at the interfaces of raw materials to drug product process & in vivo performance in the field of inhalation, supporting drug projects in the clinical phases as well as technical and feasibility projects aligned to AstraZeneca inhalation platforms.
Here you will get the opportunity to apply your excellent materials science expertise to contribute to the progression of inhaled drug projects and driving the scientific development within the field of physical science at AstraZeneca.
You will be responsible for the application and development of science in the field of particle and bulk powder characterisation, using a variety of characterisation techniques to progress the design and development of drug substance and drug products. You will join matrix style project delivery teams and work closely together with scientists specialised in formulation, analytics and biopharmaceutics to achieve successful delivery of goals in our common effort to drive the projects forward.
Main responsibilities include:
* Conduct material science and solid-state characterization of drug substances, excipients and inhaled formulations.
* Develop understanding of the link between critical material attributes, process robustness and product performance, including the impact of material variability.
* Interpret own results, consulting subject experts as required, and report outcomes and conclusions to project development team.
* Identify and assess materials risks, develop and deliver robust material science plans to support drug projects.
* Contribute to planning and execution of experimental work, including stability studies.
* Develop methods, incorporating ICH guidance as appropriate.
* Take responsibility for equipment maintenance, troubleshooting and maintaining equipment documentation.
Essential requirements
* Degree (BSc or Master +8years, or PhD+3years) in Material Science or a related subject.
* Has an excellent understanding of principles of physical chemistry related to surface properties, and knowledge in solid state properties that are linked to mechanical behaviour or surface properties.
* Experience in Material Science characterisation (size, surface, morphology) of products resulting from either size reduction, blending or spray drying processes.
* A good ability to organise, prioritise and plan own work.
* Strong oral and written communication skills and the ability to discuss complex ideas in a simple, easy to understand way.
* The ability to tackle complex scientific problems and troubleshooting.
* A strong interest and motivation to learn new technologies and concepts.
* A proven track record of working collaboratively in a team environment to deliver project objectives
Desirable requirements
* Proven track record in influencing product design using scientific material science data as well as troubleshooting experience having direct impact on decisions during product development.
* Knowledge and industrial experience of pharmaceutical development is an advantage, especially inhaled product development.
* Experience of regulatory file submissions or agencies interactions.
* Experience and understanding of how to develop relationships between material attributes, product processing and product performance.
* Practical experience and understanding of ToF-SIMS is particularly advantageous.
* Knowledge and understanding of processes used for drug substance and drug product manufacture.
* Knowledge of tools for multivariate analysis, data visualisation and predictive modelling packages.
* Awareness of processes such as spray drying and micronisation is beneficial.
* Strong influencing skills and prioritisation skills to ensure project delivery.
If you are interested, apply now! For more information about the role, please contact recruiting manager Alex Wimbush at We welcome your application no later than 7th February 2020.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2019-12-18ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2020-01-29
Klicka på denna länk för att göra din ansökanFöretagAstrazeneca AB
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-068707".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Övrig information om företaget/organisationen Offentliga upphandlingar där AstraZeneca AB varit leverantör Jobbnummer 5009808
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