Senior Scientist - In Vitro Oligo Profiling
AstraZeneca AB / Kemiingenjörsjobb / Göteborg
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hela Sverige Are you an RNA expert and would like to dedicate your passion for science and your capabilities to discover novel therapies for patients? We have an opening to join us as a Senior Scientist in the Mechanistic and Structural Biology team within the Discovery Sciences organization in Gothenburg, Sweden. You will have the opportunity to apply proven molecular biology and cell biology expertise to contribute to the discovery and development of therapeutic oligonucleotides, such as antisense oligonucleotides (ASOs) and small interfering RNA (siRNA), in a highly collaborative environment.
The successful candidate demonstrates a passion for driving scientific questions, combined with strong team working ethics, and thrive from working in drug discovery projects. You will join a team whose remit is to support our drug discovery projects globally with early DMPK assessment, SAR profiling and in-depth mechanism of action data. We offer a highly rewarding scientific environment with ample learning opportunities and an expectation to publish new findings.
Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions.
What you'll do:
This is lab-based role focused on generating in vitro data on therapeutic oligonucleotides in support of drug discovery projects. The work includes independent troubleshooting and timely reporting of data according to agreed timelines. All work is conducted in dialog with project teams, where you are expected to present and contribute in advancing the project science, specifically in support of the Cardiovascular, Renal and Metabolism as well as Respiratory & Immunology disease area organisations.
For this role, we seek a candidate with extensive molecular biology experience, especially in the characterization and quantification of RNA isoforms. The candidate will reinforce our platform for discovery and development of therapeutic oligonucleotides.
Essential for the roles:
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Candidates should have a Ph.D. or a first degree and at least 4 years' experience within a relevant scientific discipline.
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Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment.
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Strong molecular biology skills.
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Extensive experience in the development and application of assays for quantitative measurements of RNA transcripts.
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Independent analysis and evaluation of complex data and delivery of data to agreed timelines.
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First-rate decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity.
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Scientific visibility and leadership through project contributions and external publications.
Desirable for the role:
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Previous experience working with siRNA and/or ASO knockdowns.
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Experience with the RNA sequencing approaches.
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Good understanding of mRNA splicing and Gene Editing.
Why AstraZeneca?
You can ask anybody who has ever set foot here - our Gothenburg site has a vibrant culture that pulls you in! It is a mix of both local and international talent. We welcome the contribution of people from all backgrounds, beliefs and walks of life.
So, what's next? If this sounds like your next challenge - please apply today!
We look forward to your application, but please send it to us no later than August 20, 2023.
For more information about the positions please contact David Gilot at +46 72 206 97 40 or
david.gilot@astrazeneca.com.
Ersättning Not Specified
Så ansöker du Sista dag att ansöka är 2023-08-18
Klicka på denna länk för att göra din ansökan Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-175070".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca AB
Kontakt AstraZeneca
eleonor.ehrman@astrazeneca.com Jobbnummer 7980469
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