Senior Research Scientist

AstraZeneca / Biologjobb / Göteborg
2018-05-03
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At AstraZeneca we use scientific excellence as the foundation to drive success of our drug discovery pipeline. Such excellence stems from strong collaboration, clear direction and a focus on applying cutting-edge research to support drug discovery.

An opportunity is now available for a highly motivated Senior Research Scientist to join the Cellular Biology Team within the Discovery Sciences Innovative Medicine (IMED) Biotech Unit in Gothenburg, Sweden. Leading from the bench, you will apply proven skills in cellular biology, genome engineering and cell culture, a passion for investigating scientific questions, combined with strong team working ethics, to drug discovery projects. You will join our team whose remit is to support IMED projects globally with delivery of impactful cellular models used for disease target identification and validation, through screening, hit identification and lead optimisation, as well as clinical candidate evaluation.

As part of a team within the Discovery Sciences organisation, you will be working within a vibrant scientific environment to support drug discovery. We push scientific advances in small molecules, oligonucleotides as well as other emerging technologies, always with a view to providing medicines to improve patient care. The Discovery Biology Department of Discovery Sciences is responsible for the generation of novel reagents and assays to support projects in the drug discovery pipeline from target discovery all the way to clinical candidate. While we work globally, we engage most often with two main therapeutic areas that cover cardiovascular, renal and metabolic diseases (CVRM), as well as respiratory, inflammation and auto-immunity (RIA).

Main Duties & Responsibilities

This is a lab-based role, generating bespoke cellular reagents to support projects in all phases of the discovery process. The role involves application of leading genome engineering techniques to design experimental strategies, develop fit-for-purpose cellular models that impact projects, as well as troubleshooting. In addition, you will be required to make a significant contribution to the development and application of novel science to advance our capabilities in the generation of cellular models as tools in early drug discovery.

Essential Experience

* Ph.D in Biology, Pharmacology, Molecular Biology or a related discipline, or a BSc degree with significant relevant experience
* Considerable expertise in cell culture of a variety of mammalian cell types
* Substantial expertise in cellular genome engineering using a variety of techniques (with absolute requirement on the inclusion of the CRISPR/Cas system) as well as demonstrable experience in enrichment (FACS) and validation methods (sequencing, PCR and RT-PCR)
* Excellent communication skills and an ability to operate effectively in a multi-disciplinary research environment
* Independent analysis and evaluation of complex data and delivery of data to agreed timelines
* Proven ability in providing technical leadership and guidance to others
* Maintain an awareness of relevant scientific and technical advances to help identify opportunities for capability development

Desirable Experience

* Experience in cell culture of primary cells and iPSCs is highly desirable
* Experience in co-culture, 3D culture, and microphysiological systems is highly desirable
* Good understanding of drug discovery and how to translate scientific expertise into new project and business opportunities
* Scientific visibility and leadership through project contributions, internal presentations and external publications
* Excellent problem-solving skills, not limited to own area of expertise
* Clear and firm decision-making skills, coupled with tenacity to see decisions through, even in situations of ambiguity
* Track-record in publishing scientific manuscripts in peer-reviewed journals, and presenting at external conferences

If you are interested, please apply now!

For further details around this position you are welcome to contact the recruiting manager Sam Barichievy, +46 725388399;

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that we can know you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

Welcome with your application no later than June 3, 2018.

For more information about life in Gothenburg visit www.movetogothenburg.com

Varaktighet, arbetstid
Heltid Permanent

Publiceringsdatum
2018-05-03

Ersättning
Not Specified

Så ansöker du
Sista dag att ansöka är 2018-05-31
Ange följande referens när du ansöker: R-027404
Klicka på denna länk för att göra din ansökan

Kontakt
AstraZeneca karin.lyckemalm@astrazeneca.com

Företag
AstraZeneca

Adress
AstraZeneca
43183
43183 1480

Kontorsadress
Pepparredsleden 1

Jobbnummer
4122888

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Senior Research Scientist

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