Senior Research Scientist - Protacs Characterization
AstraZeneca AB / Kemistjobb / Göteborg
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hela Sverige Are you a curious scientist, motivated by challenging the boundaries of science that would like to contribute to our strategy of growth through Innovation? Do you have expertise and experience of analytical chemistry applied to cell-based assays and mass spectrometry? Perfect, this might be the position for you!
A new position has arisen for a highly motivated Senior Research Scientist to join the Mechanistic Biology & Profiling Department within the Discovery Sciences R&D organization in Gothenburg, Sweden. You will work together with existing team members to characterize molecules and their responses in biochemical and cellular assays to build a detailed understanding of their mechanism of action.
We are specifically looking for combined analytical chemistry and cell biology expertise to adopt new mass spectrometry-based approaches to understand cellular uptake and functional responses of PROTACs and to build predictive models of these actions based on their physicochemical properties.
What you'll do:
This is a lab-based role, providing dedicated experimental support to our PROTACs and other drug discovery programs. The successful candidate will deliver high-quality data to build a detailed understanding of the relation between PROTACs exposure, bioavailability, and observed pharmacology in terms of their impact on protein levels and functional responses. The work includes independent planning and execution of experiments, troubleshooting and timely reporting of data according to agreed timelines.
Essential in this role:
* Candidates should have a Ph.D. or a first degree and at least 4 years' experience within a relevant scientific discipline
* Extensive hands-on expertise in analytical chemistry applied to cell-based assays, ideally using a range of different technologies
* Significant experience with the quantitative application of mass spectrometry, e.g. in the metabolomics space
* Experience with methodologies that allow measurements of metabolites and compounds with sub-cellular resolution is considered highly meriting
* Scientific visibility and leadership through project contributions and external publications
Desirable in the role:
* Documented expertise in quantitative assessments of protein turnover
* Demonstrated abilities in linking protein levels and turnover to protein function
* Practical knowledge of the application of cellular assays for pharmacological profiling
* Proven ability in providing technical leadership and mentorship to others
* Track record of identifying and adopting scientific and technical advances
The successful candidate demonstrates a strong passion for driving scientific questions through experimental work, combined with strong team working ethics. You have good social and communication skills, is collaborative and a strong team player. You should also be able to work independently and have a positive, goal oriented and problem-solving attitude. Excellent English is required, both spoken and written, and good organisational skills are of use.
Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together.
Does this sound like the job and work place for you? Welcome to apply today!
We look forward to your application, but no later than the 5th June 2020.
For more information about the position please contact hiring manager Thomas Lundbäck at +46 72 711 66 89 or
thomas.lundback@astrazeneca.com.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2020-05-04ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2020-06-01
Klicka på denna länk för att göra din ansökanFöretagAstrazeneca AB
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-079356".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Jobbnummer 5212793
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