Senior Research Scientist - Cellular Reagents
AstraZeneca Göteborg / Apotekarjobb / Mölndal
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At AstraZeneca, innovation is more than just research. As one of the world's leading pharmaceutical companies, we're focused on providing medicines that make a real difference in patient care. AstraZeneca R&D Gothenburg, is a place where you can help us continue to lead the industry in research and development. It's also a place with an entrepreneurial and collaborative culture, where you'll feel valued, energised and rewarded for your ideas and contributions. A place where talented people can immerse themselves in their work and make significant contributions towards scientific excellence.
We are seeking a Senior Research Scientist to join our team in Gothenburg Sweden, where we focus on delivering reagents and assays primarily for Cardiovascular and Metabolic diseases and Respiratory and Autoimmunity.
You will join the Discovery Sciences organization, working within a first-class scientific environment to support drug discovery. The Reagents and Assay Development department (RAD) of Discovery Sciences, is responsible for the generation of novel cellular reagents and assays to support projects in all phases of the drug discovery pipeline.
Main Duties and Responsibilities
Applying strong expertise in the competency of cell biology, working primarily with immortalized cell lines with opportunities to use primary and iPS cells, and cellular engineering. The focus is on cell line generation using traditional and precise genome editing approaches for use in cellular assays, target identification and target validation. To devise, champion and develop scientific areas aligned with project needs. To be an authority in the arena of cell science and precise genome editing, to lead this from a lab-based perspective and make significant contributions to the practical delivery of project goals. To coach and support more junior scientists by advising and challenging them and by providing expert advice to aid interpretation of complex data. To provide disciplinary scientific leadership and represent the department at internal interdisciplinary meetings in addition to external meetings and to publish novel science in high impact journals. To propose experimental strategies, troubleshoot problems and make significant contributions to the practical delivery of projects in compliance with AstraZeneca corporate responsibility policies and relevant safety standards.
It is essential to have good social and communication skills, be collaborative and a strong team player. Candidates should be able to work independently, take own initiatives and have a positive, goal oriented and problem solving attitude. Good organisational skills are required and you should be comfortable in presenting your results. Excellent English is required, both spoken and in writing.
Tasks:
To develop cellular reagents for target based approaches and phenotypic assays, target identification, target validation
To design CRISPR-based strategies and tools required to generate cellular reagents to meet project needs
To perform confirmation of cellular/genetic manipulation and functional validation of engineered cells
To perform target identification and target validation studies in early projects
The following skills are highly desirable:
Cellular engineering using traditional and PGE methods
Cell biology and manipulation of immortalized, primary and iPSC cells
Knowledge, generation and use of viruses (lentivirus, AAV, Adenovirus) for cellular engineering and screening
Culturing and functional characterization of recombinant cell lines, primary cells and iPSC in both small (multi-well plates) and large (cell factories) scale
Essential Requirements
You should have a Ph. D. degree or corresponding experience in a relevant scientific discipline with experience in drug discovery or, alternatively, a first degree and significant relevant experience in drug discovery.
If you are interested, apply now!
For more information please contact: Ryan Hicks (+46 (0) 70 915 43 28 or Tyrrell Norris at +46 (0)72 381 07 26.
More than ever, science is accelerating our rate of understanding in a wide range of medical fields - and that's only set to increase. As a global, science-led biopharmaceutical business, AstraZeneca is at the forefront of that evolution. That means an unparalleled product portfolio and a strong pipeline across all stages of the drug development process. Everything we do comes back to improving the health of our patients worldwide, and to make that happen we're focusing on some of the most challenging diseases facing humanity today.
We have a highly collaborative culture, where you'll be encouraged to push the boundaries of science while developing industry-recognised skills and experiences.
Publiceringsdatum2017-03-06Så ansöker duSista dag att ansöka är 2017-03-31
Klicka på denna länk för att göra din ansökanFöretagAstraZeneca Göteborg
AdressAstraZeneca Göteborg
Pepparedsleden 1
43183 MÖLNDAL
KontorsadressPepparedsleden 1
Jobbnummer 3356471
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