Senior Material Scientist - Oral Product Development
AstraZeneca AB / Kemistjobb / Göteborg
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hela Sverige AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we are proud to have a unique workplace culture that inspires innovation and collaboration.
Here, employees are empowered to express diverse perspectives and are made to feel valued, energised and rewarded for their ideas and creativity.
In Pharmaceutical Technology and Development (PT&D), we are the bridge between forward-thinking science and innovative medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines - from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.
At Oral Product Development (OPD), a sub-division of Pharmaceutical Technology and Development (PT&D), we focus on the fields of Oral Controlled Release Drug products and Immediate Release Drug Products. We work on the next generation of medicines and play a key role in the development of new medicinal products.
We are currently looking for a Senior Scientist - Material Science in Oral Product Development (OPD), Gothenburg. Our vision is to transform product design and development to enable us to deliver new medicines to patients. Oral products are key growth areas for AstraZeneca, covering a wide range of projects including small molecule immediate release as well as modified release and complex formulations.
You will join a vibrant team that is working on the next generation of medicines and playing a key role in the analytical development of new medicinal products. Bring your experience in the areas of pharmaceutical analysis and your strong analytical perspective to the team and be a leader in the late stage development of new drug products.
You will deliver analytical knowledge that encompasses understanding of manufacturing processes, control strategy, robustness and stability. You will also work cross functionally with multiple internal and external interfaces, supporting drug projects from the early clinical phase through to commercial filings.
Key Responsibilities:
* Provide material science expertise in product development and conduct material science characterization of drug substances, excipients, intermediate blends and drug products.
* Plan and execute experimental work in alignment with the project objectives.
* Work collaboratively with colleagues in other functions to identify and define drug substance critical attributes and contribute to the end to end control strategy and reduce end product testing
* Develop understanding of the link between critical material attributes, process robustness and product performance, including the impact of material variability.
* Identify and assess materials risks, develop and deliver robust material science plans to support drug projects.
* Clearly communicate plans, experimental data and conclusions to project teams.
* Tackle complex scientific problems and provide lean and innovative solutions.
* Develop appropriate methods to support formulation development, and perform phase appropriate validation as required, in accordance with relevant guidelines.
Essential Requirements:
* PhD level education or equivalent experience (or BSc/MSc with industry work experience) in chemistry, chemical engineering, pharmaceutical science, material science or a relevant field.
* An excellent understanding of principles of physical chemistry related to surface properties, and particle characterization and bulk powder behaviour.
* Proven experience in material science characterization (size, surface, morphology, imaging and flow properties).
* Advanced practical expertise in characterization methods such as powder rheometry, particle size by laser diffraction or dynamic light scattering, pycnometry, specific surface area by BET and SEM imaging.
* Strong oral and written communication skills and the ability to discuss complex ideas in a simple, easy to understand way.
* The ability to tackle complex scientific problems and troubleshooting.
* A proven track record of working collaboratively in a team environment to deliver project objectives.
Desirable:
* Experience of pharmaceutical development
* Good knowledge of Python programming, and scripting.
* Experience of authoring CMC content for the relevant aspects of drug product regulatory filings throughout the clinical development phase.
* Knowledge of tools for multivariate analysis, data visualization and predictive modelling packages.
* Experience of technical supervision, coaching and mentoring
* Ability to think and operate across functional boundaries, challenge the status quo and seek opportunities for business improvement.
Why AstraZeneca?
At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.
What's next! We welcome your application, including CV and cover letter, no later than February 2nd, 2024
Ersättning Not Specified
Så ansöker du Sista dag att ansöka är 2024-02-02
Klicka på denna länk för att göra din ansökan Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-189505".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Kontakt AstraZeneca
galia.nystrom@astrazeneca.com Jobbnummer 8413958
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