Senior In Vitro Scientist, Translational Hepatic Safety
AstraZeneca AB / Kemiingenjörsjobb / Göteborg
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hela Sverige Senior In Vitro Scientist, Translational Hepatic Safety
Location: Gothenburg Sweden
Do you want to develop your lab-based curiosity about new preclinical hepatic safety techniques, influence key projects and progress into management with a world-leading pharmaceutical company? Here is your opportunity at AstraZeneca, we are seeking Senior Scientists within Translational Hepatic Safety to join us at AZ Gothenburg in Sweden, where research-led ideas are turned into new medicines that make a real difference in healthcare.
Main duties and responsibilities
* Design and deliver in vitro experimental data to support projects across the portfolio and in line with the liver organ strategy and mechanistic problem solving needed to de-risk projects
* Develop and deliver expertise in drug metabolism, biomarkers, 3D model technology with respect to the liver organ strategy
* Scientific leadership to use in depth hepatic toxicological expertise to develop and implement scientific methodology for projects, or provide specialist technical input and problem solving into toxicology issues with projects
* Evaluation and validation of the translatability of novel physiological hepatic models
* Use technical expertise and apply knowledge to lead groundbreaking projects in order to exploit new technologies and influence their adoption within AstraZeneca
* Sharing experience, knowledge and industry developments with peer scientists
* Responsible for supervision of students if required
* Interaction with staff on all levels and from all fields and areas, e.g. toxicologists, pathologists, DMPK scientists and project teams
Essential requirements
* A PhD level education (alternatively equivalent training experience) in Toxicology, Pharmacology, Biomedical Science or related field
* Significant experience in a relevant scientific field
* Extensive experience in the area of liver biology, hepatic injury, drug metabolism
* Extensive training in cell culture, sterile work and 3D culture e.g. spheroids
* Expertise in either novel in vitro hepatic models, hepatic biomarkers, BSep / bile acid transport, reactive metabolites, cholestasis, mitochondrial toxicity or related mechanism of hepatic toxicity providing specialised competence in that area
* An ability to think and act creatively both independently, and within teamworks
* Highly motivated, innovative scientist with the ability to influence and with a team-oriented approach
* Excellent English language skills, both spoken and in writing
Desirable requirements
* A detailed understanding of drug metabolism, pharmacokinetics
* Knowledge of lab automation tools for making in vitro work more efficient
* Scientific experience in liver disease area including NAFLD, NASH, etc.
* Theoretical knowledge and long term experience of relevant techniques and technologies
* Well founded understanding of AstraZeneca's business objectives that are related to R&D
Why AstraZeneca?
Join a place built on innovation and creativity. Where different views and perspectives are welcomed and valued. Be part of a dedicated Research & Development team. Fuelled by our commitment to help more patients, strengthen our pipeline and grow our area.
So, what's next? If this sounds like a challenge for you - apply today!
We look forward to get to know you better. Send in your application as soon as possible, but no later than 19th of October.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2022-09-28ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2022-10-19
Klicka på denna länk för att göra din ansökanFöretagAstrazeneca AB
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-149040".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Kontakt AstraZeneca
kristina.krsteska@astrazeneca.com Jobbnummer 7022560
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