Senior In Vitro Adme Scientist
AstraZeneca / Kemistjobb / Göteborg
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hela Sverige Placement: AstraZeneca R&D, Gothenburg, Sweden
We are now recruiting a Senior in vitro ADME scientist to join the DMPK department within the Cardiovascular and Metabolic Diseases (CVMD) therapeutic area.
CVMD is one of the three main therapeutic research area within Innovative Medicines and Early Development (IMED) which deliver candidate drugs into late-stage clinical development. CVMD is based in AstraZeneca's world-class vibrant R&D center, located in Gothenburg, Sweden. CVMD DMPK interacts with other functions in supporting CVMD projects all along the value chain, from target selection all the way to market launch and Life cycle management.
As a Senior in vitro ADME scientist you will be part of a team at the forefront of DMPK science focusing on metabolism, disposition, and analysis of small molecule, peptide and nucleotide drug candidates. You will have the opportunity to contribute to the discovery of new life changing medicines for patients and demonstrate and witness what science can do.
Main Duties and Responsibilities
We'll look to you to act as an expert in your area providing proficient scientific advice on all aspects of drug disposition to project teams. You will execute and provide significant input into the practical delivery of project goals across all modalities in the portfolio as well as develop and implement novel approaches.
As an in vitro ADME expert you will:
* Be responsible for design, conduct, interpretation and reporting of in vitro ADME studies. You will apply state of the art in-vitro DMPK science across drug discovery and development to support compound design and project progression.
* Provide scientific leadership, mentorship and laboratory supervision internally of less experienced scientists and training and development of scientific talents.
* Provide scientific leadership by leading and driving collaborations with key academic centres and by presenting work through lectures and publications in top-tier scientific journals.
* Identify improvements in technologies that can be successfully applied to a highly competitive drug discovery or development paradigm that contributes to achievement of short and long term business goals and influences strategic direction.
* May be part of cross-functional work-streams and lead the development and implementation of DMPK scientific strategies, and act as a catalyst for scientific debate within the AstraZeneca science community.
Essential requirements
* PhD degree or equivalent qualification, and at least three years postdoctoral experience
* Background in Pharmacy, Biology, Biochemistry, Medical Biosciences or similar
* Broad knowledge about ADME processes and relevant in-vitro models of drug disposition, and track record in development, characterization and application of translatable in-vitro models beyond the liver
* Versatile in in-vitro laboratory skills (e.g. handling of human cells and tissues, enzyme and transporter kinetic studies, principles of molecular and imaging analysis)
* Scientific leadership, evidenced by a publication track record and ability to independently lead the drafting and review of publication manuscripts.
* Good communication skills in English, both verbal and in writing are required
* Excellent interpersonal skills
Desirable requirements:
* Good understanding of renal pharmacokinetics and their study in vitro
* Experience in bioanalytical techniques, e.g. LC-MS
* Knowledge in omics technologies and bioinformatics
* Experience from industry environment a plus, but not mandatory.
This is an exciting opportunity for a talented ADME scientist to join a strong team at the forefront of DMPK science, to innovate and support the portfolio of a major pharmaceutical company that has science at its heart and a tremendously strong pipeline whilst being based in the wonderful city of Gothenburg, Sweden.
If you are interested, apply now!
For more information about the position please contact:
hiring manager Constanze Hilgendorf
• 46(0)702 29 25 45
Welcome with your application no later than October 22, 2017.
AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2017-09-28ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2017-10-19
Ange följande referens när du ansöker: R-014524
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
katinka.larssen@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparedsleden 1
Jobbnummer 3723304
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