Senior Bioinformatician for Oligonucleotide Therapeutics

AstraZeneca AB / Biomedicinjobb / Göteborg
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Are you a quantitatively-minded scientist looking to apply bioinformatics and machine learning to design oligonucleotides for therapeutic use? At AstraZeneca, we turn ideas into life changing medicines. Working here means thinking big and working together to deliver impact from our contributions that make the impossible a reality.


We have an exciting opportunity to join our Data Sciences and Quantitative Biology team that works as part of the Discovery Sciences organisation, within BioPharma R&D and contribute as a Senior Bioinformatician for Oligonucleotide Therapeutics. This position will be based at our vibrant R&D site in Gothenburg, Sweden.

Discovery Sciences work with all AstraZeneca therapy areas to deliver candidate drugs into late-stage clinical development. The Data Sciences and Quantitative Biology team is a multi-disciplinary team of data scientists with the purpose of providing quantitative insights to biology. In partnership with our experimentalist colleagues, we provide computational analysis and solutions to enable and drive our drug discovery efforts forward.

What you will do
As Senior Bioinformatician for Oligonucleotide therapeutics, you'll be using bioinformatics and machine learning to identify and deliver oligonucleotide sequence designs. You will be responsible for developing and internalizing appropriate algorithms, techniques and datasets to advance our ability to rapidly discover oligonucleotide candidate drugs.

You will also enhance our data analysis capabilities on complex, high-dimensional omics data to identify biologically induced effects of oligonucleotides. Further you will be contributing to and leading local and global projects for NGS applied in oligonucleotide projects and ensuring that results are scientifically robust and documented.


Essential for the role

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PhD, or equivalent, in bioinformatics, mathematics, computer science, statistics, engineering or the life sciences
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Expertise and experience in therapeutic oligonucleotide sequence design and analysis
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Expertise in one or more of the competency areas: DNA/RNA sequence analysis, next generation sequencing analysis, multivariate and/or high dimensional omics data analysis
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Experience with relevant software tools such as R and/or Python
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Proficiency in working in a Linux environment, experience with shell scripting and standard command line tools
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Understanding of molecular biology, cell biology, and human physiology, ontologies, data management, machine learning, statistical modelling
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Experience with tools for reproducible research such as git, conda, Snakemake or Nextflow
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Excellent English, spoken and in writing



To be successful, we expect you to demonstrate a passion for driving scientific questions and being capable of receiving and analysing input from multiple fields and deciding on focused course of action. You have a consistent track record of delivering analytical solutions for business or academic needs. You are able to work independently and have a positive, result-oriented and problem-solving attitude. We also believe that you enjoy teamwork, have a collaborative nature and will be an encouraging colleague to all.


Why AstraZeneca?
AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity


So, what's next!
Does this sound like your next position? Apply now!

We will continuously review applications and look forward to your application no later than August 11, 2024.

For more information about the position please contact hiring manager Fredrik Karlsson at Fredrik.H.Karlsson@astrazeneca.com


Additional information:
Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html
Life in Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Ersättning
Not Specified

Så ansöker du
Sista dag att ansöka är 2024-07-25
Klicka på denna länk för att göra din ansökan

Arbetsgivarens referens
Arbetsgivarens referens för detta jobb är "R-202914".

Omfattning
Detta är ett heltidsjobb.

Arbetsgivare
Astrazeneca AB (org.nr 556011-7482)

Arbetsplats
AstraZeneca

Kontakt
AstraZeneca
karin.tomin@astrazeneca.com

Jobbnummer
8801122

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