Senior Bioanalytical and Biomarker Scientist
AstraZeneca AB / Kemistjobb / Göteborg
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hela Sverige AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. At AstraZeneca, we're proud to have an inspiring workplace culture that encourages innovation and collaboration. Here, employees are empowered to express diverse perspectives and are made to feel valued, energized and rewarded for their ideas and creativity.
We are now recruiting a Senior Bioanalytical and Biomarker Scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) department within the Early Respiratory, Inflammation and Autoimmunity (Early RIA) therapeutic area. You will be part of the In Vitro and In Vivo Science team where in vivo and in vitro studies are performed and subsequent bio-analysis of drugs, drug metabolites and biomarkers using state of the art LCMS instruments. The position is placed at AstraZeneca's vibrant R&D site in Gothenburg, Sweden.
As a Senior Bioanalytical and Biomarker Scientist, you will be responsible for delivering quality in vitro and in vivo bioanalytical data of drugs and biomarkers to support PKPD (Pharmacokinetics and Pharmacodynamics) work in projects from target selection to LCM (life cycle management). The data produced is mainly sought to provide insight in quantitative pharmacology as well as in right tissue and right exposure. The samples include different tissues and a variety of biological fluids as well as sub-cellular fractions. In addition to the quantitative analyses this role also includes characterization and structure elucidation of metabolites in biological samples. With proven experience from LC-MS/MS analysis, you are encouraged to develop and implement novel approaches and provide significant input to drug project decision making.
This laboratory based scientific role includes developing methods to enable delivery of the necessary quality of data and scientific input aligned with drug project needs. The role requires interactive, effective communication to provide clear data and guidance to project representatives, act as an example to other scientists, and play a vital role in the overall team delivery. You will also be required to make judgements about bioanalytical input, developing innovative solutions and applying cross-functional and industry understanding. You will have the opportunity to contribute to the discovery of new life changing medicines for patients and demonstrate and witness what science can do.
Essential requirements
* Background in analytical chemistry, medicinal chemistry or equivalent with at least five years' experience relevant to the position
* In-depth experience of quantitative LC-MSMS including firsthand competence of analysing small molecules, peptides, proteins and oligonucleotide-based drugs as well as endogenous compounds.
* Technical skills to operate, perform regular maintenance and elementary trouble shooting of LC-MSMS instruments.
* Excellent hands-on skills of sample preparation of biofluids for quantification of drugs and endogenous compounds, method development included.
* A proven record of delivering state-of-the-art bioanalytical and biomarker data to projects in discovery and/or development setting.
* Outstanding communication and interpersonal skills.
* Excellent English, both verbal and written.
* Strong ability to engage and collaborate across boundaries with a problem-solving attitude and focus on delivery.
* Bring a fresh perspective into the group and the enthusiasm to seek new challenges and learn new skills.
Other preferable skills
* Experiences in high resolution MS instruments for structure elucidation.
* Good organic chemistry knowledge
We would like to know more about you. If you are interested to know more about us, apply now!
Welcome with your application no later than 2019-12-01
Additional information
Our Gothenburg site:
https://www.astrazeneca.com/our-science/gothenburg.htmlCulture and atmosphere of the Gothenburg site:
https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/Life in Gothenburg and Sweden:
https://www.movetogothenburg.com/About AstraZeneca Gothenburg
Our stunning campus in Gothenburg is one of AstraZeneca's three strategic science centers. The site is home to over 2,500 employees, from 50 different nationalities. Gothenburg includes the complete range of functions, and as such offers plenty of development opportunities for a wide range of professionals. And the site itself has been designed with collaboration in mind. From the Coffee Lab to exercise areas, we've created a series of environments where innovation can happen.
AstraZeneca is acting as an Employment Agency in relation to this vacancy.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2019-11-11ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2019-11-30
Klicka på denna länk för att göra din ansökanFöretagAstrazeneca AB
Arbetsgivarens referens Arbetsgivarens referens för detta jobb är "R-065640".
Omfattning Detta är ett heltidsjobb.
Arbetsgivare Astrazeneca AB (org.nr 556011-7482)
Arbetsplats AstraZeneca
Jobbnummer 4951249
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