Preclinical And Translational Pk & Pkpd Scientist
AstraZeneca / Apotekarjobb / Göteborg
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hela Sverige Do you have expertise in pharmacokinetics and pharmacodynamics? Would you like to apply your expertise in a company that is following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!
We are now recruiting a Senior Scientist with expertise in pharmacokinetics-pharmacodynamics (PKPD) to join the DMPK department within the Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.
CVRM is one of the three main therapeutic research areas within Innovative Medicines and Early Development (IMED), AstraZeneca's small molecule biotech unit that deliver candidate drugs into late-stage clinical development. CVRM is based in AstraZeneca's world-class vibrant R&D center, located in Gothenburg, Sweden. CVRM DMPK interacts with other functions in supporting CVMD projects all along the value chain, from target selection all the way to market launch and Life cycle management.
As a Senior PK and PKPD scientist you will provide pharmacokinetic-pharmacodynamic (PKPD) input and modelling on a broad range of drug modalities in the cardiovascular, renal and metabolism disease area. The main task will be to deliver translational quantitative/PKPD input and strategies to projects from target identification to life-cycle management. You are anticipated to have a solid PKPD understanding and have hands-on mathematical modelling experience (e.g. empirical PKPD models, in vitro-in vivo translation, non-linear mixed effects models, mechanistic systems pharmacology models). You will have the opportunity to contribute to the discovery of new life changing medicines for patients and demonstrate and witness what science can do.
Main Duties and Responsibilities
* Define and deliver the translational quantitative/PKPD strategy for efficacy and target safety, in projects from target identification to life-cycle management
* Identify the appropriate mathematical modelling approach (e.g. traditional PKPD modelling, non-linear mixed effects modelling, quantitative systems pharmacology) to deliver quantitative translational project input from target identification to life-cycle management
* Design preclinical PKPD studies, contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies
* In collaboration with key functions (e.g. bioscientists, translational scientists, safety scientists, clinical pharmacologists and clinical pharmacometricians) integrate the appropriate data to predict human pharmacokinetics, efficacious drug exposure, human longitudinal response (e.g. biomarker and disease effects), and human dosing regimen
* Be up to date with emerging literature and continuously display scientific progress externally and internally
* Deliver drug-drug interaction (DDI) predictions and risk assessments to project teams
* Key Deliverables: Deliver the PK, DDI and PKPD elements to project teams within the agreed timelines and to the right quality
Essential Requirements
* PhD or equivalent level of experience in mathematical modelling and simulation of PKPD or quantitative systems pharmacology and ideally in a preclinical/translational setting
* Specialist in modelling and simulation tools such as Matlab, R, NONMEM, WinNonlin/Phoenix NLME, SimCyp
* Experience of defining quantitative modelling strategies across several therapeutic modalities (e.g. small molecules, oligonucleotides, proteins, antibodies) is an advantage
* Track record of ability to meet timelines to pre-specified quality and cost
* Understanding of integrative aspects of DMPK and pharmacology/safety aspects of drug discovery and development
* Experience in pharmaceutical R&D and experience in operating cross-functionally
If you are interested, apply now!
For more information about the position please contact Rasmus Jansson Lofmark at Rasmus.
Welcome with your application no later than May 20, 2018
AstraZeneca is a global, innovation-driven pharmaceutical company focussing on the discovery, development and commercialization of novel medicines. At AstraZeneca, we are proud to have a unique culture that inspires innovation and collaboration both within the company and with external partners. Employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.
Varaktighet, arbetstid
Heltid Permanent
Publiceringsdatum2018-04-23ErsättningNot Specified
Så ansöker duSista dag att ansöka är 2018-05-21
Ange följande referens när du ansöker: R-026826
Klicka på denna länk för att göra din ansökanKontaktAstraZeneca
ulrica.marklund1@astrazeneca.comFöretagAstraZeneca
AdressAstraZeneca
43183
43183 1480
KontorsadressPepparedsleden 1
Jobbnummer 4102614
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