Postdoctoral Researcher in Tumor Biology
Karolinska Institutet, Department of Microbiology, Tumor and Cel / Biologjobb / Solna
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Division MTC offers an opportunity for postdoctoral research studies in Tumor Biology.
The research of the Arsenian Henriksson group is focused on the childhood cancer neuroblastoma. Today, neuroblastoma ranks as the most common and aggressive solid tumor in infants with 90% of cases diagnosed by age 5. Amplification of the MYCN oncogene is found in approximately 30% of all neuroblastoma cases and is associated with poor prognosis and chemotherapy resistance.
Duties
The group has previously demonstrated that MYCN inhibition leads to metabolic alterations and results in lipid accumulation in neuroblastoma cells (Zirath et al., PNAS 2013). The aim of the current project is to study how MYCN controls the energy metabolism in neuroblastoma using a combination of proteomics, metabolic profiling and gene expression dataset analysis. (Cell Reports 2016 and Dzieran et al., PNAS 2018.)
Entry requirements
Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence.
We are looking for a highly motivated, creative, responsible researcher who has the capacity to work independently as well as in a team. A PhD degree awarded in cancer biology with experience in neuroblastoma and metabolism is required. The applicant should have a strong background in molecular cell biology and cancer metabolism. Practical experience of standard cell biology techniques, including advanced real time metabolic functional assays in mammalian cells. Experience of design of in vitro and in vivo studies; analysis of proteomic and genomic data and expert skills in statistical evaluation of data. The successful candidate needs to have experience of design and analysis of in vivo as well as in vitro drug studies. Previous experience in training master students is an advantage.
Application process
An employment application must contain the following documents in English or Swedish:
- A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
- A complete list of publications
- A summary of current work (no more than one page)
- Verifications for crediting of illness, military service, work for labor unions or student organizations, parental leave or similar circumstances
- A brief letter of motivation (no more than one page)
- Contact details for two reference persons.
The application is to be submitted through the Varbi recruitment system.
Karolinska Institutet is one of the world's leading medical universities. Its vision is to significantly contribute to the improvement of human health. Karolinska Institutet accounts for the single largest share of all academic medical research conducted in Sweden and offers the country's broadest range of education in medicine and health sciences. The Nobel Assembly at Karolinska Institutet selects the Nobel laureates in Physiology or Medicine.
Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.
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Varaktighet, arbetstid
100%. Tillträde: enl. ök Visstidsanställning
Publiceringsdatum2019-01-21Ersättningmånadslön
Så ansöker duSista dag att ansöka är 2019-02-11
Ange följande referens när du ansöker: 2-414/2019
Klicka på denna länk för att göra din ansökanKontaktMarie Arsenian Henriksson, Professor 08-524 862 05
FöretagKarolinska Institutet, Department of Microbiology, Tumor and Cel
AdressKarolinska Institutet, Department of Microbiology, Tumor and Cel
Nobels väg 16, KI Solna Campus, Karolinska Instit
17177 Stockholm
KontorsadressNobels väg 16, KI Solna Campus, Karolinska Instit
Jobbnummer 4567318
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