Postdoctoral researcher in the domain of systems biology and met
Örebro universitet / Sjukgymnastjobb / Örebro
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hela Sverige The School of Medical Sciences is seeking a postdoctoral researcher in the domain of systems biology and metabolomics as related to the studies of non-alcoholic fatty liver disease (NAFLD) for a fixed-term appointment.
Duties and responsibilities
The post-doctoral researcher will be a key person in two projects aiming to elucidate the biomarkers and the underlying pathways in the progression of NAFLD: (1) ongoing Horizon 2020 project EPoS - Elucidating Pathways of Steatohepatitis and (2) new IMI project LITMUS - Liver Investigation: Testing Marker Utility in Steatohepatitis (starting in the Fall 2017).
The research focus is on applications of multivariate and genome-scale metabolic modelling approaches to identify the key pathways and markers associated with progression of NAFLD - based on multiomics data including metabolomics (plasma and human liver biopsies), RNAseq (liver biopsies) and metagenomics (gut microbiota) from multiple human cohort studies. In LITMUS, the aim is also to translate the research findings into the diagnostic application. The researcher will also be involved in planning of metabolomics experiments at Örebro University.
Recent relevant publications of the research team:
• K. Luukkonen, et al. Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease. J Hepatol 64(5), 1167-1175 (2016).
• Hyötyläinen, et al. Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease. Nat Comm 7, 8994 (2016).
• K. Pedersen, et al. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature 535, 376-381 (2016).
Eligibility
Eligible for the appointment as postdoctoral researcher are applicants holding a doctoral degree in bioinformatics, systems biology, metabolomics or in related subject areas. The doctoral degree should have been awarded no more than three years prior to the application deadline. Candidates who have obtained their doctoral degree prior to that may however also be considered if special grounds exist (leave of absence due to illness, parental leave, clinical duties, an elected position in a trade union, or other similar circumstances).
Assessment criteria
Documented knowledge and experience in biochemistry, biostatistics and statistical learning, involving analysis of biological high-throughput data is a requirement. Experience with medical applications of metabolomics, genome-scale metabolic modelling, and metabolic research in general are merits. The applicant should be proficient in the R statistical language. The successful candidate should be creative, have the ability to both co-operate and independently work with research questions. Proficiency in written and spoken English is a requirement. General assessment criteria include good interpersonal skills and an ability to cooperate as well as the ability and suitability otherwise required to perform the duties well.
Equality
Our ambition is to create a place of work that is characterised by gender equality and diversity.
Information
The position is a full-time position for a fixed term of two years, starting in January 2018. The salary depends on the successful candidate's qualifications and experience.
For more information, please contact Matej Oresic (+358 44 972 6094,
matej.oresic@oru.se).
Application
The application is made online. Click the button "Apply" to begin the application procedure.
For the application to be complete, the following electronic documents must be included:
• Covering letter
• CV
• An account of [research/artistic] qualifications
• Copies of relevant course/degree certificates and references
• Scientific publications for consideration (maximum of 10)
Only documents written in Swedish, English, Norwegian and Danish can be reviewed.
The application deadline is November 15, 2017. We look forward to receiving your application!
We decline any contact with advertisers or recruitment agencies in the recruitment process.
As directed by the National Archives of Sweden (Riksarkivet), Örebro University is required to deposit one file copy of the application documents, excluding publications, for a period of two years after the appointment decision has gained legal force.
Varaktighet, arbetstid
Heltid/ Ej specificerat
Publiceringsdatum2017-10-13ErsättningIndividuell lönesättning
Så ansöker duSista dag att ansöka är 2017-11-15
Klicka på denna länk för att göra din ansökanFöretagÖrebro Universitet
AdressÖrebro Universitet
Fakultetsgatan 1
70182 Örebro
KontorsadressFakultetsgatan 1
Jobbnummer 3748774
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